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. 1972 Mar;22(3):457–463.

Detection of antinuclear antibodies in NZB and other mouse strains

B V Siegel, M Brown, Jane I Morton
PMCID: PMC1407784  PMID: 4554746

Abstract

Employing formalinized chicken erythrocyte nuclei as substrate for indirect immunofluorescence assay it was possible to detect antinuclear antibodies (ANA) in the plasma of very young New Zealand Black (NZB) mice. While 7–10-day-old animals gave uniformly negative responses, weak ANA was detected in about 12 per cent of NZB mice at 14 days of age, with strong reactivity demonstrable in 90 per cent of mice by the time they were 5 weeks old. Quantification of immunofluorescence indicated that ANA reactivity of NZB plasma increased with age as measured up to 2 years. During the first year of life, mice of C57B1, CBA, C3H, BALB/c, AKR, A, SJL and 129/J strains manifested largely negative and weak reactions. However, by 1–2 years of age these animals showed marked increases in incidence of strongly reactive ANA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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