Skip to main content
Immunology logoLink to Immunology
. 1968 Feb;14(2):265–272.

A new class of immunoglobulins in human serum

S G O Johansson, H Bennich, L Wide
PMCID: PMC1409295  PMID: 4170889

Abstract

A new class of normal immunoglobulin corresponding to a myeloma protein (myeloma-IgND), which fails to react with specific antisera to IgA, D, G and M (Johansson and Bennich, 1967) was detected in serum from sixty-two blood donors using a radio-immunosorbent technique (Wide and Porath, 1966).

IgND in normal sera corresponds to myeloma-IgND in Ouchterlony gel diffusion analysis.

Isolated IgND gave a reaction of identity with myeloma-IgND in Ouchterlony gel diffusion analysis.

The concentrations of IgND in 93·5 per cent of the samples was within the range of 100–700 ng/ml.

Normal levels of IgND were found in four samples apparently lacking IgA and/or IgD as determined by single radial immunodiffusion.

Elevated levels of IgND were found in four samples one of which was from a subject with previously undiagnosed extrinsic asthma.

It is concluded that myeloma-IgND represents a new class of human immunoglobulin.

Full text

PDF
267

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Axén R., Porath J. Chemical coupling of enzymes to cross-linked dextran ('Sephadex'). Nature. 1966 Apr 23;210(5034):367–369. doi: 10.1038/210367a0. [DOI] [PubMed] [Google Scholar]
  2. EGGSTEIN M., KREUTZ F. H. Vergleichende Untersuchungen zur quantitativen Eiweissbestimmung im Liquor und eiweissarmen Lösungen. Klin Wochenschr. 1955 Oct 1;33(37-38):879–884. doi: 10.1007/BF01473099. [DOI] [PubMed] [Google Scholar]
  3. HUNTER W. M., GREENWOOD F. C. Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature. 1962 May 5;194:495–496. doi: 10.1038/194495a0. [DOI] [PubMed] [Google Scholar]
  4. Johansson S. G., Bennich H. Immunological studies of an atypical (myeloma) immunoglobulin. Immunology. 1967 Oct;13(4):381–394. [PMC free article] [PubMed] [Google Scholar]
  5. KUNKEL H. G. Zone electrophoresis. Methods Biochem Anal. 1954;1:141–170. doi: 10.1002/9780470110171.ch6. [DOI] [PubMed] [Google Scholar]
  6. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  7. ROWE D. S., FAHEY J. L. A NEW CLASS OF HUMAN IMMUNOGLOBULINS. I. A UNIQUE MYELOMA PROTEIN. J Exp Med. 1965 Jan 1;121:171–184. doi: 10.1084/jem.121.1.171. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES