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. 1967 Aug;13(2):141–145.

Tolerance in adult rabbits by repeated non-immunogenic doses of bovine serum albumin

G J Thorbecke, B Benacerraf
PMCID: PMC1409309  PMID: 4952100

Abstract

A series of multiple intravenous injections of bovine serum albumin, starting with doses too small to be immunogenic, has been used for the induction of tolerance in adult rabbits. With normal outbred animals, approximately 50 per cent of the rabbits were rendered completely tolerant by an injection schedule with 0.1 mg as the initial dose and a total dose of 9 mg given over a period of 5–7 weeks. The mechanism of this `low-dose tolerance' is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIRO C. E., GARCIA G. THE ANTIGENICITY OF AGGREGATED AND AGGREGATE-FREE HUMAN GAMMA-GLOBULIN FOR RABBITS. Immunology. 1965 Apr;8:411–419. [PMC free article] [PubMed] [Google Scholar]
  2. CLAMAN H. N. TOLERANCE TO A PROTEIN ANTIGEN IN ADULT MICE AND THE EFFECT OF NONSPECIFIC FACTORS. J Immunol. 1963 Dec;91:833–839. [PubMed] [Google Scholar]
  3. Cohen S., Vassalli P., Benacerraf B., McCluskey R. T. The distribution of antigenic and nonantigenic compounds within draining lymph nodes. Lab Invest. 1966 Jul;15(7):1143–1155. [PubMed] [Google Scholar]
  4. DRESSER D. W. Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen. Immunology. 1962 May;5:378–388. [PMC free article] [PubMed] [Google Scholar]
  5. FREI P. C., BENACERRAF B., THORBECKE G. J. PHAGOCYTOSIS OF THE ANTIGEN, A CRUCIAL STEP IN THE INDUCTION OF THE PRIMARY RESPONSE. Proc Natl Acad Sci U S A. 1965 Jan;53:20–23. doi: 10.1073/pnas.53.1.20. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. MITCHISON N. A. INDUCTION OF IMMUNOLOGICAL PARALYSIS IN TWO ZONES OF DOSAGE. Proc R Soc Lond B Biol Sci. 1964 Dec 15;161:275–292. doi: 10.1098/rspb.1964.0093. [DOI] [PubMed] [Google Scholar]
  7. McConahey P. J., Dixon F. J. A method of trace iodination of proteins for immunologic studies. Int Arch Allergy Appl Immunol. 1966;29(2):185–189. doi: 10.1159/000229699. [DOI] [PubMed] [Google Scholar]
  8. Paul W. E., Siskind G. W., Benacerraf B. A study of the 'termination' of tolerance to BSA with DNP-BSA in rabbits: relative affinities of the antibodies for the immunizing and the paralysing antigens. Immunology. 1967 Aug;13(2):147–157. [PMC free article] [PubMed] [Google Scholar]
  9. STAVITSKY A. B. Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. J Immunol. 1954 May;72(5):360–367. [PubMed] [Google Scholar]
  10. Schwartz R. S. Specificity of immunosuppression by antimetabolites. Fed Proc. 1966 Jan-Feb;25(1):165–168. [PubMed] [Google Scholar]
  11. Sobey W. R., Magrath J. M., Reisner A. H. Genetically controlled specific immunological unresponsiveness. Immunology. 1966 Nov;11(5):511–513. [PMC free article] [PubMed] [Google Scholar]
  12. THORBECKE G. J., MAURER P. H., BENACERRAF B. The affinity of the reticulo-endothelial system for various modified serum proteins. Br J Exp Pathol. 1960 Apr;41:190–197. [PMC free article] [PubMed] [Google Scholar]

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