Abstract
Delayed-type hypersensitivity and antibody formation to sheep erythrocytes (SRBC) was studied in rats. Two immunologically specific suppressive effects on the primary induction of delayed hypersensitivity were found: one was short-lasting and due to a direct action of intravenous antigen; the other was mediated by anti-SRBC antibody and demonstrable both as a later-occurring and indirect effect of active immunization and as occurring consequent to passive immunization. Either of these two forms of suppression only partially prevented primary induction of delayed hypersensitivity, but used together their effects were synergistic and completely suppressed development of delayed hypersensitivity. The secondary delayed hypersensitivity response was insusceptible to antibody inhibition.
The data concerning delayed hypersensitivity to SRBC in the rat were in some ways analogous to previous findings concerning induction of haemolytic plaque-forming cells to SRBC in the same animal. The interpretation that delayed hypersensitivity and humoral antibody formation could represent alternative responses of potential antibody-forming cells to immunological induction was considered.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Asherson G. L., Stone S. H. Selective and specific inhibition of 24 hour skin reactions in the guinea-pig. I. Immune deviation: description of the phenomenon and the effect of splenectomy. Immunology. 1965 Sep;9(3):205–217. [PMC free article] [PubMed] [Google Scholar]
- COOPER M. D., PETERSON R. D., GOOD R. A. DELINEATION OF THE THYMIC AND BURSAL LYMPHOID SYSTEMS IN THE CHICKEN. Nature. 1965 Jan 9;205:143–146. doi: 10.1038/205143a0. [DOI] [PubMed] [Google Scholar]
- Cooper M. D., Raymond D. A., Peterson R. D., South M. A., Good R. A. The functions of the thymus system and the bursa system in the chicken. J Exp Med. 1966 Jan 1;123(1):75–102. doi: 10.1084/jem.123.1.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DVORAK H. F., BILLOTE J. B., MCCARTHY J. S., FLAX M. H. IMMUNOLOGIC UNRESPONSIVENESS IN THE ADULT GUINEA PIG. I. SUPPRESSION OF DELAYED HYPERSENSITIVITY AND ANTIBODY FORMATION TO PROTEIN ANTIGENS. J Immunol. 1965 Jun;94:966–975. [PubMed] [Google Scholar]
- JERNE N. K., NORDIN A. A. Plaque formation in agar by single antibody-producing cells. Science. 1963 Apr 26;140(3565):405–405. [PubMed] [Google Scholar]
- Loewi G., Holborow E. J., Temple A. Inhibition of delayed hypersensitivity by pre-immunization without complete adjuvant. Immunology. 1966 Apr;10(4):339–347. [PMC free article] [PubMed] [Google Scholar]
- Miller J. F. Immunity in the foetus and the new-born. Br Med Bull. 1966 Jan;22(1):21–26. doi: 10.1093/oxfordjournals.bmb.a070431. [DOI] [PubMed] [Google Scholar]
- NOSSAL G. J., SZENBERG A., ADA G. L., AUSTIN C. M. SINGLE CELL STUDIES ON 19S ANTIBODY PRODUCTION. J Exp Med. 1964 Mar 1;119:485–502. doi: 10.1084/jem.119.3.485. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PAPERMASTER B. W., CONDIE R. M., FINSTAD J., GOOD R. A. EVOLUTION OF THE IMMUNE RESPONSE. I. THE PHYLOGENETIC DEVELOPMENT OF ADAPTIVE IMMUNOLOGIC RESPONSIVENESS IN VERTEBRATES. J Exp Med. 1964 Jan 1;119:105–130. doi: 10.1084/jem.119.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROWLEY D. A., CHUTKOW J., ATTIG C. Severe active cutaneous hypersensitivity in the rat produced by Hemophilus pertussis vaccine. J Exp Med. 1959 Nov 1;110:751–769. doi: 10.1084/jem.110.5.751. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROWLEY D. A., FITCH F. W. HOMEOSTASIS OF ANTIBODY FORMATION IN THE ADULT RAT. J Exp Med. 1964 Dec 1;120:987–1005. doi: 10.1084/jem.120.6.987. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wortis H. H., Taylor R. B., Dresser D. W. Antibody production studied by means of the LHG assay. I. The splenic response of CBA mice to sheep erythrocytes. Immunology. 1966 Dec;11(6):603–616. [PMC free article] [PubMed] [Google Scholar]