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. 1968 Dec;15(6):827–835.

Studies on the immune reconstitution of sublethally irradiated mice by peritoneal macrophages

Harriet Gershon, Michael Feldman
PMCID: PMC1409488  PMID: 4884963

Abstract

Studies were performed on the reconstitution of the immune response to Shigella paradysenteriae and sheep erythrocytes in sublethally irradiated mice by the injection of normal peritoneal macrophages with and without pre-incubation with antigen. The response to Shigella was found to be less radiosensitive than the anti-SRBC response. Sublethally irradiated mice (550 r) injected with peritoneal macrophages from normal donors pre-incubated with Shigella antigen or injected simultaneously with macrophages and Shigella evinced a strong anti-Shigella response. No such reconstitution of the immune response against SRBC was observed, even when lower irradiation doses and phagocytosis-enhancing incubation media were used. Possible reasons for the different response to Shigella and SRBC are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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