Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1969 Mar;16(3):361–371.

Opsonic, cytophilic and agglutinating activity of guinea-pig γ2 and γM anti-Salmonella antibodies

P Del Guercio, G Tolone, F Braga Andrade, G Biozzi, R A Binaghi
PMCID: PMC1409614  PMID: 4890312

Abstract

Guinea-pig anti-Salmonella typhimurium antibodies of the γ2 and γM classes were obtained free of each other, and their properties were studied quantitively. Macroglobulin antibodies were found to be about twenty times more efficient than γ2, in agglutination and opsonic activity in vivo. The cytophilic activity of both classes of antibodies was the same.

Full text

PDF
363

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENACERRAF B., OVARY Z., BLOCH K. J., FRANKLIN E. C. Properties of guinea pig 7S antibodies. I. Electrophoretic separation of two types of guinea pig 7S antibodies. J Exp Med. 1963 Jun 1;117:937–949. doi: 10.1084/jem.117.6.937. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BLOCH K. J., KOURILSKY F. M., OVARY Z., BENACERRAF B. PROPERTIES OF GUINEA PIG 7S ANTIBODIES. IV. ANTIBODY RESPONSE TO E. COLI BACTERIA. Proc Soc Exp Biol Med. 1963 Oct;114:52–56. doi: 10.3181/00379727-114-28583. [DOI] [PubMed] [Google Scholar]
  3. BOYDEN S. V. CYTOPHILIC ANTIBODY IN GUINEA-PIGS WITH DELAYED-TYPE HYPERSENSITIVITY. Immunology. 1964 Jul;7:474–483. [PMC free article] [PubMed] [Google Scholar]
  4. Berken A., Benacerraf B. Properties of antibodies cytophilic for macrophages. J Exp Med. 1966 Jan 1;123(1):119–144. doi: 10.1084/jem.123.1.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Binaghi R. A. Production of 7 S immunoglobulins in immunized guinea pigs. J Immunol. 1966 Aug;97(2):159–164. [PubMed] [Google Scholar]
  6. Binaghi R., Oriol R. Anticorps purifiés de type macroglobuline. Bull Soc Chim Biol (Paris) 1968 Sep 28;50(5):1035–1040. [PubMed] [Google Scholar]
  7. HERZENBERG L. A., WARNER N. L., HERZENBERG L. A. IMMUNOGLOBULIN ISOANTIGENS (ALLOTYPES) IN THE MOUSE. I. GENETICS AND CROSS-REACTIONS OF THE 7S GAMMA-2A-ISOANTIGENS CONTROLLED BY ALLELES AT THE IG-1 LOCUS. J Exp Med. 1965 Mar 1;121:415–438. doi: 10.1084/jem.121.3.415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. McConahey P. J., Dixon F. J. A method of trace iodination of proteins for immunologic studies. Int Arch Allergy Appl Immunol. 1966;29(2):185–189. doi: 10.1159/000229699. [DOI] [PubMed] [Google Scholar]
  9. Onoue K., Tanigaki N., Yagi Y., Pressman D. IgM and IgG anti-hapten antibody: hemolytic, hemagglutinating and precipitating activity. Proc Soc Exp Biol Med. 1965 Nov;120(2):340–346. doi: 10.3181/00379727-120-30531. [DOI] [PubMed] [Google Scholar]
  10. ROBBINS J. B., KENNY K., SUTER E. THE ISOLATION AND BIOLOGICAL ACTIVITIES OF RABBIT GAMMA M- AND GAMMA G-ANTI-SALMONELLA TYPHIMURIUM ANTIBODIES. J Exp Med. 1965 Aug 1;122:385–402. doi: 10.1084/jem.122.2.385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Rowley D., Turner K. J. Number of molecules of antibody required to promote phagocytosis of one bacterium. Nature. 1966 Apr 30;210(5035):496–498. doi: 10.1038/210496a0. [DOI] [PubMed] [Google Scholar]
  12. SPIEGELBERG H. L., MIESCHER P. A., BENACERRAF B. STUDIES ON THE ROLE OF COMPLEMENT IN THE IMMUNE CLEARANCE OF ESCHERICHIA COLI AND RAT ERYTHROCYTES BY THE RETICULOENDOTHELIAL SYSTEM IN MICE. J Immunol. 1963 May;90:751–759. [PubMed] [Google Scholar]
  13. STELOS P., TALMAGE D. W. The separation by starch electrophoresis of two antibodies in sheep red cells differing in hemolytic efficiency. J Infect Dis. 1957 Mar-Apr;100(2):126–135. doi: 10.1093/infdis/100.2.126. [DOI] [PubMed] [Google Scholar]
  14. Smith J. W., Barnett J. A., May F. P., Sanford J. P. Comparison of the opsonic activity of gamma-G- and gamma-M-anti-Proteus globulins. J Immunol. 1967 Feb;98(2):336–343. [PubMed] [Google Scholar]
  15. THORBECKE G. J., BENACERRAF B., OVARY Z. ANTIGENIC RELATIONSHIP BETWEEN TWO TYPES OF 7 S GUINEA PIG GAMMA-GLOBULINS. J Immunol. 1963 Nov;91:670–676. [PubMed] [Google Scholar]
  16. WEILER R. J., HOFSTRA D., SZENTIVANYI A., BLAISDELL R., TALMAGE D. W. The inhibition of labeled antigen precipitation as a measure of serum gamma-globulin. J Immunol. 1960 Aug;85:130–137. [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES