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. 1969 Apr;16(4):543–548.

Homocytotropic antibody in sheep

R S Hogarth-Scott
PMCID: PMC1409650  PMID: 5770393

Abstract

It has been possible to demonstrate, using the homologous passive cutaneous anaphylaxis (PCA) reaction, the presence of homocytotropic (reagin-like) antibody in the sera of sheep infected with Ostertagia. The presence of antibody was detectable with Evans blue dye, and a radiolabelled 131I technique. The antibody appeared to fulfil the criteria for homocytotropic antibody, and reacted with an allergenic extract (molecular weight 20,000–50,000) of Ostertagia.

An in vitro radio-allergo-absorption method using IgG1A (a new sheep immunoglobulin sub-class) failed to detect homocytotropic antibody, although the Fc fragment of goat anti-sheep IgG1A was capable of blocking the PCA reaction, and of producing a reversed-type allergic skin reaction.

This homocytotropic antibody is probably associated with the `self-cure' reaction in Ostertagia infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baumgarten A., Melrose G. J., Vagg W. J. Continuous quantitative recording of changes in vascular permeability. Experientia. 1967 Oct 15;23(10):884–885. doi: 10.1007/BF02146911. [DOI] [PubMed] [Google Scholar]
  2. Becker E. L., Austen K. F. Mechanisms of immunologic injury of rat peritoneal mast cells. I. The effect of phosphonate inhibitors on the homocytotropic antibody-mediated histamine release and the first component of rat complement. J Exp Med. 1966 Sep 1;124(3):379–395. doi: 10.1084/jem.124.3.379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bloch K. J. The anaphylactic antibodies of mammals including man. Prog Allergy. 1967;10:84–150. [PubMed] [Google Scholar]
  4. Cohen S., Milstein C. Structure and biological properties of immunoglobulins. Adv Immunol. 1967;7:1–89. doi: 10.1016/s0065-2776(08)60126-1. [DOI] [PubMed] [Google Scholar]
  5. Coombs R. R., Hunter A., Jonas W. E., Bennich H., Johannson S. G., Panzani R. Detection of IgE(IgND) specific antibody (probably reagin) to castor-bean allergen by the red-cell-linked antigen-antiglobulin reaction. Lancet. 1968 May 25;1(7552):1115–1118. doi: 10.1016/s0140-6736(68)90186-4. [DOI] [PubMed] [Google Scholar]
  6. Coombs R. R. Immunopathology. Br Med J. 1968 Mar 9;1(5592):597–602. doi: 10.1136/bmj.1.5592.597. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Curtain C. C. A new immunoglobulin sub-class in the sheep. Immunology. 1969 Mar;16(3):373–380. [PMC free article] [PubMed] [Google Scholar]
  8. Hogarth-Scott R. S. Rabbit reagin-like antibodies. Int Arch Allergy Appl Immunol. 1967;32(2):201–207. doi: 10.1159/000229928. [DOI] [PubMed] [Google Scholar]
  9. Hogarth-Scott R. S. The molecular weight range of nematode allergens. Immunology. 1967 Nov;13(5):535–537. [PMC free article] [PubMed] [Google Scholar]
  10. Ishizaka K., Ishizaka T. Reversed type allergic skin reactions by anti-gamma-E-globulin antibodies in humans and monkeys. J Immunol. 1968 Mar;100(3):554–562. [PubMed] [Google Scholar]
  11. OGILVIE B. M. REAGIN-LIKE ANTIBODIES IN ANIMALS IMMUNE TO HELMINTH PARASITES. Nature. 1964 Oct 3;204:91–92. doi: 10.1038/204091a0. [DOI] [PubMed] [Google Scholar]
  12. Rockey J. H., Schwartzman R. M. Skin sensitizing antibodies: a comparative study of canine and human PK and PCA antibodies and a canine myeloma protein. J Immunol. 1967 Jun;98(6):1143–1151. [PubMed] [Google Scholar]
  13. Wide L., Bennich H., Johansson S. G. Diagnosis of allergy by an in-vitro test for allergen antibodies. Lancet. 1967 Nov 25;2(7526):1105–1107. doi: 10.1016/s0140-6736(67)90615-0. [DOI] [PubMed] [Google Scholar]
  14. Wilson R. J. Homocytotropic antibody response to the nematode Nippostrongylus brasiliensis in the rat--studies on the worm antigen. J Parasitol. 1967 Aug;53(4):752–762. [PubMed] [Google Scholar]

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