Skip to main content
PMC home page
Gut logoLink to Gut
. 1975 Apr;16(4):255–260. doi: 10.1136/gut.16.4.255

Estimation of carcinoembryonic antigen in ulcerative colitis with special reference to malignant change.

J B Dilawari, J E Lennard-Jones, A M Mackay, J K Ritchie, H G Sturzaker
PMCID: PMC1410925  PMID: 1132800

Abstract

The levels of plasma carcinoembryonic antigen (CEA) were estimated in 59 control subjects attending St Mark's Hospital and in 139 patients with uncomplicated ulcerative colitis. There was little difference in the CEA levels in the two groups. In the colitic patients, the actual CEA values could not be correlated with the age of the patient, the activity of the disease, the extent of bowel involvement, or the length of history. In addition, seven colitic patients with severe dysplastic changes in the rectal mucosa and seven patients with established carcinoma in colitis were studied. With one exception in each group, the CEA levels in these patients were within the range shown by the St Mark's Hospital control population.

Full text

PDF
260

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Booth S. N., King J. P., Leonard J. C., Dykes P. W. Serum carcinoembryonic antigen in clinical disorders. Gut. 1973 Oct;14(10):794–799. doi: 10.1136/gut.14.10.794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Egan M. L., Lautenschleger J. T., Coligan J. E., Todd C. W. Radioimmune assay of carcinoembryonic antigen. Immunochemistry. 1972 Mar;9(3):289–299. doi: 10.1016/0019-2791(72)90093-6. [DOI] [PubMed] [Google Scholar]
  3. GOLD P., FREEDMAN S. O. DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES. J Exp Med. 1965 Mar 1;121:439–462. doi: 10.1084/jem.121.3.439. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Khoo S. K., Hunt P. S., Mackay I. R. Studies of carcinoembryonic antigen activity of whole and extracted serum in ulcerative colitis. Gut. 1973 Jul;14(7):545–548. doi: 10.1136/gut.14.7.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Khoo S. K., Mackay I. R. Carcinoembryonic antigen in serum in diseases of the liver and pancreas. J Clin Pathol. 1973 Jul;26(7):470–475. doi: 10.1136/jcp.26.7.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Krupey J., Gold P., Freedman S. O. Purification and characterization of carcinoembryonic antigens of the human digestive system. Nature. 1967 Jul 1;215(5096):67–68. doi: 10.1038/215067a0. [DOI] [PubMed] [Google Scholar]
  7. Laurence D. J., Stevens U., Bettelheim R., Darcy D., Leese C., Turberville C., Alexander P., Johns E. W., Neville A. M. Role of plasma carcinoembryonic antigen in diagnosis of gastrointestinal, mammary, and bronchial carcinoma. Br Med J. 1972 Sep 9;3(5827):605–609. doi: 10.1136/bmj.3.5827.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lo Gerfo P., Krupey J., Hansen H. J. Demonstration of an antigen common to several varieties of neoplasia. N Engl J Med. 1971 Jul 15;285(3):138–141. doi: 10.1056/NEJM197107152850302. [DOI] [PubMed] [Google Scholar]
  9. Moore T. L., Kantrowitz P. A., Zamcheck N. Carcinoembryonic antigen (CEA) in inflammatory bowel disease. JAMA. 1972 Nov 20;222(8):944–947. [PubMed] [Google Scholar]
  10. Morson B. C., Pang L. S. Rectal biopsy as an aid to cancer control in ulcerative colitis. Gut. 1967 Oct;8(5):423–434. doi: 10.1136/gut.8.5.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Rule A. H., Goleski-Reilly C., Sachar D. B., Vandevoorde J., Janowitz H. D. Circulating carcinoembryonic antigen (CEA): relationship to clinical status of patients with inflammatory bowel disease. Gut. 1973 Nov;14(11):880–884. doi: 10.1136/gut.14.11.880. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Stevens D. P., Mackay I. R. Increased carcinoembryonic antigen in heavy cigarette smokers. Lancet. 1973 Dec 1;2(7840):1238–1239. doi: 10.1016/s0140-6736(73)90975-6. [DOI] [PubMed] [Google Scholar]
  13. Thomson D. M., Krupey J., Freedman S. O., Gold P. The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system. Proc Natl Acad Sci U S A. 1969 Sep;64(1):161–167. doi: 10.1073/pnas.64.1.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Unger A., Panayi G. S., Lessof M. H. Carcinoembryonic antigen in rheumatoid arthritis. Lancet. 1974 Apr 27;1(7861):781–783. doi: 10.1016/s0140-6736(74)92845-1. [DOI] [PubMed] [Google Scholar]
  15. Wight D. G., Gazet J. C. Carcino-embryonic antigen levels in inflammatory disease of the large bowel. Proc R Soc Med. 1972 Nov;65(11):967–968. [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES