Abstract
Intestinal biopsies from 146 patients with adult coeliac disease and 13 patients with intestinal villous atrophy of different aetiology were assessed for the presence of subepithelial collagen and compared with a group of 20 control subjects. Subepithelial collagen was a common and non-specific finding observed in intestinal biopsies from patients suffering from adult coeliac disease (36%) and tropical sprue. In adult coeliac disease the described subepithelial changes usually regress following treatment, though marked subepithelial collagen deposition may indicate a poor prognosis. The study showed that the presence of marked subepithelial collagen in a flat jejunal biopsy does not define a separate clinical entity.
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- A case of adult coeliac disease resistant to treatment. Br Med J. 1968 Jun 15;2(5606):678–684. doi: 10.1136/bmj.2.5606.678. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COOKE W. T., FONE D. J., COX E. V., MEYNELL M. J., GADDIE R. ADULT COELIAC DISEASE. Gut. 1963 Sep;4:279–291. doi: 10.1136/gut.4.3.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Doe W., Henry K., Holt L., Booth C. C. An immunological study of adult coeliac disease. Gut. 1972 Apr;13(4):324–325. [PubMed] [Google Scholar]
- HOURIHANE D. O. DIARRHOEA OF SMALL BOWEL ORIGIN. THE HISTOLOGY OF INTESTINAL BIOPSIES. Proc R Soc Med. 1963 Dec;56:1073–1077. [PMC free article] [PubMed] [Google Scholar]
- Holdstock D. J., Oleesky S. Successful treatment of collagenous sprue with combination of prednisolone and gluten-free diet. Postgrad Med J. 1973 Sep;49(575):664–667. doi: 10.1136/pgmj.49.575.664. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Non-responsive coeliac disease. Br Med J. 1972 Sep 9;3(5827):624–631. [PMC free article] [PubMed] [Google Scholar]
- Weinstein W. M., Saunders D. R., Tytgat G. N., Rubin C. E. Collagenous sprue--an unrecognized type of malabsorption. N Engl J Med. 1970 Dec 10;283(24):1297–1301. doi: 10.1056/NEJM197012102832401. [DOI] [PubMed] [Google Scholar]