Skip to main content
PMC home page
Gut logoLink to Gut
. 1975 Aug;16(8):590–597. doi: 10.1136/gut.16.8.590

Mucosal changes in gastric ulceration and their response to carbenoxolone sodium.

H W Steer, D G Colin-Jones
PMCID: PMC1411007  PMID: 810394

Abstract

The epithelial differences between the normal stomach (six subjects) and 47 patients with gastric ulcers were compared. The concentrations of intraepithelial lymphocytes and polymorphonuclear leucocytes in lesser curve and prepyloric gastirc ulcers were compared, the effect of treatment with carbenoxolone sodium was studied. There is a statistically significant reduction in the total number of intraepithelial polymorphonuclear leucocytes before and after successful treatment with carbenoxolone sodium. There is also a statistically significant decrease in the quantity of intraepithelial lymphocytes in those patients with lesser curve gastric ulcers successfully treated with carbenoxolone sodium, whereas there is a significant increase in those patients with prepyloric gastric ulcers successfully treated and those patients in whom treatment failed. The value of counts of migrating white blood cells as a method of objectively assessing the effect of healing drugs upon the gastric mucosa is discussed. Pseudomonas aeruginosa was found in many specimens obtained, and evidence is presented that this was not a contaminant. Carbenoxolone appeared to increase the amount of mucus but had little effect upon the number of bacteria found. The possible contribution of Pseudomonas aeruginosa to gastric ulceration is discussed.

Full text

PDF
594

Images in this article

591Fig 1
on p.591
592Fig 2
on p.592
593Fig 3
on p.593
594Fig 4
on p.594

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Axon A. T., Phillips I., Cotton P. B., Avery S. A. Disinfection of gastrointestinal fibre endoscopes. Lancet. 1974 Apr;1(7859):656–658. doi: 10.1016/s0140-6736(74)93202-4. [DOI] [PubMed] [Google Scholar]
  2. BARON J. H. AN ASSESSMENT OF THE AUGMENTED HISTAMINE TEST IN THE DIAGNOSIS OF PEPTIC ULCER. CORRELATIONS BETWEEN GASTRIC SECRETION, AGE AND SEX OF PATIENTS, AND SITE AND NATURE OF THE ULCER. Gut. 1963 Sep;4:243–253. doi: 10.1136/gut.4.3.243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Capper W. M. Factors in the pathogenesis of gastric ulcer. Hunterian lecture delivered at the Royal College of Surgeons of England on 18th January 1966. Ann R Coll Surg Engl. 1967 Jan;40(1):21–35. [PMC free article] [PubMed] [Google Scholar]
  4. DUPLESSIS D. J. PATHOGENESIS OF GASTRIC ULCERATION. Lancet. 1965 May 8;1(7393):974–978. doi: 10.1016/s0140-6736(65)91214-6. [DOI] [PubMed] [Google Scholar]
  5. Gear M. W., Truelove S. C., Whitehead R. Gastric ulcer and gastritis. Gut. 1971 Aug;12(8):639–645. doi: 10.1136/gut.12.8.639. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gheorghiu T., Frotz H., Klein H. J. Experimentelle und klinische Untersuchungen zum mechanismus der Carbenoxolon-Wirkung. I. Einfluss von Carbenoxolon auf die Magensaft-Mucus-sekretion der Ratte. Verh Dtsch Ges Inn Med. 1971;77:511–515. [PubMed] [Google Scholar]
  7. Giannella R. A., Broitman S. A., Zamcheck N. Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro. Gut. 1972 Apr;13(4):251–256. doi: 10.1136/gut.13.4.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Goodier T. E., Horwich L., Galloway R. W. Morphological observations on gastric ulcers treated with carbenoxolone sodium. Gut. 1967 Dec;8(6):544–547. doi: 10.1136/gut.8.6.544. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Johnson A. G., McDermott S. J. Lysolecithin: a factor in the pathogenesis of gastric ulceration? Gut. 1974 Sep;15(9):710–713. doi: 10.1136/gut.15.9.710. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. RICHARDSON K. C., JARETT L., FINKE E. H. Embedding in epoxy resins for ultrathin sectioning in electron microscopy. Stain Technol. 1960 Nov;35:313–323. doi: 10.3109/10520296009114754. [DOI] [PubMed] [Google Scholar]
  11. Rhodes J., Barnardo D. E., Phillips S. F., Rovelstad R. A., Hofmann A. F. Increased reflux of bile into the stomach in patients with gastric ulcer. Gastroenterology. 1969 Sep;57(3):241–252. [PubMed] [Google Scholar]
  12. Rhodes J. Etiology of gastric ulcer. Gastroenterology. 1972 Jul;63(1):171–182. [PubMed] [Google Scholar]
  13. Robinson E. P. Pseudomonas aeruginosa contamination of liquid antacids: a survey. J Pharm Sci. 1971 Apr;60(4):604–605. doi: 10.1002/jps.2600600421. [DOI] [PubMed] [Google Scholar]
  14. Thomas E., Hall P., Hislop I. G. Observations on the histology of the gastric mucosa in chronic gastric ulcer. Am J Dig Dis. 1972 Aug;17(8):683–688. doi: 10.1007/BF02231635. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES