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. 1976 Jul;17(7):542–550. doi: 10.1136/gut.17.7.542

Gastric emptying in control subjects and patients with duodenal ulcer before and after vagotomy.

P J Howlett, H J Sheiner, D C Barber, A S Ward, C A Perez-Avila, H L Duthie
PMCID: PMC1411168  PMID: 964687

Abstract

The emptying of a solid meal labelled with Indium 113mDTPA from the stomach was studied with a gamma camera in 26 normal subjects, 27 patients with duodenal ulcer, on 41 occasions after truncal vagotomy and pyloroplasty and 38 times after highly selective vagotomy. Applying the method of principal component analysis to the results, differences were detected between control and duodenal ulcer subjects and two probable subgroups of duodenal ulcer were observed. Half emptying times did not reveal these patterns. After vagotomy, delayed emptying was general at one week. At one month, patients after highly selective vagotomy had a more normal result than those with truncal vagotomy and pyloroplasty (TV), but by six months no significant difference in overall emptying rate was found, although changes in the pattern of gastric emptying persisted in some patients after TV.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander-Williams J., Donovan I. A., Gunn I. F., Brown A., Harding L. K. The effect of vagotomy on gastric emptying. Proc R Soc Med. 1973 Nov;66(11):1102–1103. [PMC free article] [PubMed] [Google Scholar]
  2. Amdrup E., Jensen H. E., Johnston D., Walker B. E., Goligher J. C. Clinical results of parietal cell vagotomy (highly selective vagotomy) two to four years after operation. Ann Surg. 1974 Sep;180(3):279–284. doi: 10.1097/00000658-197409000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Buckler K. G. Effects of gastric surgery upon gastric emptying in cases of peptic ulceration. Gut. 1967 Apr;8(2):137–147. doi: 10.1136/gut.8.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Carlson H. C., Code C. F., Nelson R. A. Motor action of the canine gastroduodenal junction: a cineradiographic, pressure, and electric study. Am J Dig Dis. 1966 Feb;11(2):155–172. doi: 10.1007/BF02239239. [DOI] [PubMed] [Google Scholar]
  5. Clarke R. J., Alexander-Williams J. The effect of preserving antral innervation and of a pyloroplasty on gastric emptying after vagotomy in man. Gut. 1973 Apr;14(4):300–307. doi: 10.1136/gut.14.4.300. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cobb J. S., Bank S., Marks I. N., Louw J. H. Gastric emptying after vagotomy and pyloroplasty. Relation to some postoperative sequelae. Am J Dig Dis. 1971 Mar;16(3):207–215. doi: 10.1007/BF02235241. [DOI] [PubMed] [Google Scholar]
  7. Cowley D. J., Vernon P., Jones T., Glass H. I., Cox A. G. Gastric emptying of solid meals after truncal vagotomy and pyloroplasty in human subjects. Gut. 1972 Mar;13(3):176–181. doi: 10.1136/gut.13.3.176. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. De Dombal F. T., Horrocks J. C., Clamp S. E. Proceedings: Observer variation in the assessment of results of surgery for peptic ulceration. Gut. 1974 Oct;15(10):824–824. [PubMed] [Google Scholar]
  9. Fordtran J. S., Walsh J. H. Gastric acid secretion rate and buffer content of the stomach after eating. Results in normal subjects and in patients with duodenal ulcer. J Clin Invest. 1973 Mar;52(3):645–657. doi: 10.1172/JCI107226. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. George J. D. Gastric acidity and motility. Am J Dig Dis. 1968 Apr;13(4):376–383. doi: 10.1007/BF02233017. [DOI] [PubMed] [Google Scholar]
  11. Griffith G. H., Owen G. M., Campbell H., Shields R. Gastric emptying in health and in gastroduodenal disease. Gastroenterology. 1968 Jan;54(1):1–7. [PubMed] [Google Scholar]
  12. Howlett P. J., Ward A. S., Duthie H. L. Gastric emptying after vagotomy. Proc R Soc Med. 1974 Sep;67(9):836–838. [PMC free article] [PubMed] [Google Scholar]
  13. Humphrey C. S., Johnston D., Walker B. E., Pulvertaft C. N., Goligher J. C. Incidence of dumping after truncal and selective vagotomy with pyloroplasty and highly selective vagotomy without drainage procedure. Br Med J. 1972 Sep 30;3(5830):785–788. doi: 10.1136/bmj.3.5830.785. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Humphrey C. S., Wilkinson A. R. The value of preserving the pylorus in the surgery of duodenal ulcer. Br J Surg. 1972 Oct;59(10):779–783. doi: 10.1002/bjs.1800591009. [DOI] [PubMed] [Google Scholar]
  15. Johnston D., Wilkinson A. R. Highly selective vagotomy without a drainage procedure in the treatment of duodenal ulcer. Br J Surg. 1970 Apr;57(4):289–296. doi: 10.1002/bjs.1800570414. [DOI] [PubMed] [Google Scholar]
  16. Kelly J. M., Kennedy T. L. Does highly selective vagotomy preserve antral motility? Gut. 1971 Oct;12(10):866–866. [PubMed] [Google Scholar]
  17. Köster N., Madsen P. The intragastric pressure before and immediately after truncal vagotomy. Scand J Gastroenterol. 1970;5(5):381–383. [PubMed] [Google Scholar]
  18. Madsen P., Kronborg O., Feldt-Rasmussen K. The gastric emptying and small intestinal transit after highly selective vagotomy without drainage and selective vagotomy with pyloroplasty. Scand J Gastroenterol. 1973;8(6):541–543. [PubMed] [Google Scholar]
  19. McKelvey S. T. Gastric incontinence and post-vagotomy diarrhoea. Br J Surg. 1970 Oct;57(10):741–747. doi: 10.1002/bjs.1800571012. [DOI] [PubMed] [Google Scholar]
  20. Stadaas J., Aune S. Intragastric pressure-volume relationship before and after vagotomy. Acta Chir Scand. 1970;136(7):611–615. [PubMed] [Google Scholar]
  21. Stoddard C. J., Waterfall W. E., Brown B. H., Duthie H. L. The effects of varying the extent of the vagotomy on the myoelectrical and motor activity of the stomach. Gut. 1973 Aug;14(8):657–664. doi: 10.1136/gut.14.8.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Wilbur B. G., Kelly K. A. Effect of proximal gastric, complete gastric, and truncal vagotomy on canine gastric electric activity, motility, and emptying. Ann Surg. 1973 Sep;178(3):295–303. doi: 10.1097/00000658-197309000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]

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