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. 1977 Jan;18(1):73–77. doi: 10.1136/gut.18.1.73

Nitrite and thiocyanate in the fasting and secreting stomach and in saliva.

W S Ruddell, L M Blendis, C L Walters
PMCID: PMC1411255  PMID: 838407

Abstract

The concentrations of nitrite and thiocyanate in fasting and pentagastrin stimulated gastric juice and in saliva have been examined. Nitrite was found in all of 17 samples of fasting gastric juice, mean 4-9 +/- 1-1 muM. Stimulation of gastric secretion with pentagastrin caused no significant change in nitrite concentration. Thiocyanate was detected in all of 21 samples of fasting gastric juice and the difference in concentration between smokers and non-smokers probably reflects similar differences in saliva. In contrast to the nitrite data there was a significant drop in thiocyanate concentration of gastric juice after pentagastrin from 0-9 +/- 0-1 mM to 0-3 +/- 0-04 mM, suggesting a salivary origin for the thiocyanate in gastric juice. Thiocyanate is a powerful catalyst of nitrosation, which, together with small amounts of nitrite and naturally occurring amines could lead to the intragastric formation of carcinogenic nitrosamines and in certain circumstances be a factor in the aetiology of gastric cancer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adriaanse A., Robbers J. E. Determination of nitrite and nitrate in some horticultural and meat products and in samples of soil. J Sci Food Agric. 1969 Jun;20(6):321–325. doi: 10.1002/jsfa.2740200601. [DOI] [PubMed] [Google Scholar]
  2. Boyland E., Walker S. A. Effect of thiocyanate on nitrosation of amines. Nature. 1974 Apr 12;248(449):601–602. doi: 10.1038/248601a0. [DOI] [PubMed] [Google Scholar]
  3. Clendinnen B. G., Reeder D. D., Davidson W. D., Thompson J. C. Effect of gastrointestinal hormones on salivation in the dog. Arch Surg. 1970 Nov;101(5):596–598. doi: 10.1001/archsurg.1970.01340290052011. [DOI] [PubMed] [Google Scholar]
  4. Fujita M., Taguchi T., Takami M., Usugane M., Takahashi A. Carcinoma and related lesion in dog stomach induced by oral administration of N-methyl-N'-nitro-n-nitrosoguanidine. Gan. 1974 Jun;65(3):207–214. [PubMed] [Google Scholar]
  5. Hawksworth G. M., Hill M. J. Bacteria and the N-nitrosation of secondary amines. Br J Cancer. 1971 Sep;25(3):520–526. doi: 10.1038/bjc.1971.66. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hawksworth G., Hill M. J. The in vivo formation of N-nitrosamines in the rat bladder and their subsequent absorption. Br J Cancer. 1974 May;29(5):353–358. doi: 10.1038/bjc.1974.82. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Heathcote J. G., Washington R. Amino-acids and peptides in human gastric juice with particular reference to pernicious anaemia: a review. Nature. 1965 Aug 28;207(5000):941–944. doi: 10.1038/207941a0. [DOI] [PubMed] [Google Scholar]
  8. Hill M. J., Hawksworth G., Tattersall G. Bacteria, nitrosamines and cancer of the stomach. Br J Cancer. 1973 Dec;28(6):562–567. doi: 10.1038/bjc.1973.186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Langman M. J., Doll R., Wilson J. Plasma and salivary thiocyanate in gastric cancer. Gut. 1966 Oct;7(5):549–552. doi: 10.1136/gut.7.5.549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lijinsky W., Epstein S. S. Nitrosamines as environmental carcinogens. Nature. 1970 Jan 3;225(5227):21–23. doi: 10.1038/225021a0. [DOI] [PubMed] [Google Scholar]
  11. Lijinsky W., Taylor H. W., Snyder C., Nettesheim P. Malignant tumours of liver and lung in rats fed aminopyrine or heptamethyleneimine together with nitrite. Nature. 1973 Jul 20;244(5412):176–178. doi: 10.1038/244176a0. [DOI] [PubMed] [Google Scholar]
  12. Magee P. N., Barnes J. M. Carcinogenic nitroso compounds. Adv Cancer Res. 1967;10:163–246. doi: 10.1016/s0065-230x(08)60079-2. [DOI] [PubMed] [Google Scholar]
  13. Mirvish S. S. Kinetics of dimethylamine nitrosation in relation to nitrosamine carcinogenesis. J Natl Cancer Inst. 1970 Mar;44(3):633–639. [PubMed] [Google Scholar]
  14. Schweinsberg F., Sander J., Schweinsberg E., Kollat P. Untersuchungen über die Nitrosiergarkeit von Nicotin und Nornicotin und über die Frage der Bildung con N-Nitrosonornicotin im Magen von Rauchern. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975 Sep 22;84(1):81–87. doi: 10.1007/BF00305692. [DOI] [PubMed] [Google Scholar]
  15. Sen N. P., Smith D. C., Schwinghamer L. Formation of N-nitrosamines from secondary amines and nitrite in human and animal gastric juice. Food Cosmet Toxicol. 1969 Jul;7(4):301–307. doi: 10.1016/s0015-6264(69)80366-4. [DOI] [PubMed] [Google Scholar]
  16. Tannenbaum S. R., Sinskey A. J., Weisman M., Bishop W. Nitrite in human saliva. Its possible relationship to nitrosamine formation. J Natl Cancer Inst. 1974 Jul;53(1):79–84. [PubMed] [Google Scholar]
  17. Zacho A., Nielsen J., Larsen V. Smoking habits of patients with gastric cancer. Acta Chir Scand. 1971;137(5):455–458. [PubMed] [Google Scholar]

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