Abstract
Hypovolaemia alone did not lead to ischaemic colitis but when venesection was induced immediately after the acute ligation of the common colic artery large bowel ischaemia ensued. Similarly, hypovolaemia induced one month after two major blood vessels had been occluded led to ischaemic colitis. These findings suggest that states of low blood flow in the presence of previous arterial constriction or blockage may lead to enough reduction in mesenteric perfusion for intestinal ischaemia to develop. Using an electromagnetic flowmeter placed in the cranial mesenteric artery of the dog, it was shown that hypovolaemia may lead to 50-75% reduction in mesenteric blood flow without producing any significant change in the systemic blood pressure.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Britt L. G., Cheek R. C. Nonocclusive mesenteric vascular disease: clinical and experimental observations. Ann Surg. 1969 May;169(5):704–711. doi: 10.1097/00000658-196905000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DERRICK J. R., POLLARD H. S., MOORE R. M. The pattern of arteriosclerotic narrowing of the celiac and superior mesenteric arteries. Ann Surg. 1959 May;149(5):684–689. doi: 10.1097/00000658-195905000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HARDAWAY R. M., 3rd, McKAY D. G. Pseudomembranous enterocolitis; are antibiotics wholly responsible. AMA Arch Surg. 1959 Mar;78(3):446–457. [PubMed] [Google Scholar]
- HEDBERG C. A., KIRSNER J. B. MESENTERIC VASCULAR INSUFFICIENCY. Ann Intern Med. 1965 Sep;63:535–538. doi: 10.7326/0003-4819-63-3-535. [DOI] [PubMed] [Google Scholar]
- Herrington J. L., Jr Multiple focal necrosis of the colon in the absence of occlusion of the mesenteric blood supply. Am J Surg. 1965 Dec;110(6):981–984. doi: 10.1016/0002-9610(65)90193-5. [DOI] [PubMed] [Google Scholar]
- JENSON C. B., SMITH G. A. A clinical study of 51 cases of mesenteric infarction. Surgery. 1956 Nov;40(5):930–937. [PubMed] [Google Scholar]
- Marston A., Pheils M. T., Thomas M. L., Morson B. C. Ischaemic colitis. Gut. 1966 Feb;7(1):1–15. doi: 10.1136/gut.7.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marston A. Vascular disorders of the colon. Acta Chir Belg. 1967 Dec 2;Suppl 2:80–92. [PubMed] [Google Scholar]
- Matsumoto T., Hardaway R. M., 3rd, McClain J. E. Microcirculation in hemorrhagic shock with relationship to blood pressure. Arch Surg. 1967 Dec;95(6):911–917. doi: 10.1001/archsurg.1967.01330180059011. [DOI] [PubMed] [Google Scholar]
- Montessori G., Liepa E. V. Ischemic colitis. Can Med Assoc J. 1970 Feb 28;102(4):377–380. [PMC free article] [PubMed] [Google Scholar]
- RUSSELL J. Y. W. Inferior mesenteric vascular occlusion. Br J Surg. 1950 Jan;37(147):321–323. doi: 10.1002/bjs.18003714716. [DOI] [PubMed] [Google Scholar]
- Ranniger K., Scheiner D. L. Experimental bowel ischemia. Arch Surg. 1967 Nov;95(5):768–770. doi: 10.1001/archsurg.1967.01330170076010. [DOI] [PubMed] [Google Scholar]
- Rosati L. A., Augur N. A., Jr Ischemic enterocolitis in pheochromocytoma. Gastroenterology. 1971 Apr;60(4):581–585. [PubMed] [Google Scholar]
- SELKURT E. E., SCIBETTA M. P., CULL T. E. Hemodynamics of intestinal circulation. Circ Res. 1958 Jan;6(1):92–99. doi: 10.1161/01.res.6.1.92. [DOI] [PubMed] [Google Scholar]
- Williams L. F., Jr, Anastasia L. F., Hasiotis C. A., Bosniak M. A., Byrne J. J. Nonocclusive mesenteric infarction. Am J Surg. 1967 Sep;114(3):376–381. doi: 10.1016/0002-9610(67)90159-6. [DOI] [PubMed] [Google Scholar]