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. 1977 Mar;18(3):191–195. doi: 10.1136/gut.18.3.191

Plasma secretin and pancreatic bicarbonate response to exogenous secretin in man.

W H HACKI, S R Bloom, P Mitznegg, W Domschke, S Domschke, D Belohlavek, L Demling, E Wünsch
PMCID: PMC1411398  PMID: 852751

Abstract

The dose response of duodenal bicarbonate production during synthetic porcine secretin infusions was studied in six healthy volunteers and related to plasma secretin immunoreactivity. Secretin was infused in each individual at four different doses from 0-1 to 2-7 CU/kg/h, each infusion lasting for 60 minutes. Mean maximal bicarbonate secretion was 33 +/- 4 mEq/h. The secretin plasma level for half maximal bicarbonate response was estimated to be 22 pmol/l. As this level is reported to be achieved by intraduodenal acidification in man, it is concluded that secretin may well play a part in the control of duodenal pH.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berstad A., Roland M., Petersen H., Liaväg I. The pancreatic exocrine secretion in duodenal ulcer patients before and after selective proximal vagotomy of the stomach. Scand J Gastroenterol. 1974;9(5):431–436. [PubMed] [Google Scholar]
  2. Bloom S. R., Ward A. S. Failure of secretin release in patients with duodenal ulcer. Br Med J. 1975 Jan 18;1(5950):126–127. doi: 10.1136/bmj.1.5950.126. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Boden G., Essa N., Owen O. E., Reichle F. A. Effects of intraduodenal administration of HCl and glucose on circulating immunoreactive secretin and insulin concentrations. J Clin Invest. 1974 Apr;53(4):1185–1193. doi: 10.1172/JCI107657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bryant M. G., Bloom S. R. Proceedings: Characterization of the new gastrointestinal hormones. Gut. 1975 Oct;16(10):840–840. [PubMed] [Google Scholar]
  5. Farooq O., Sturdevant R. A., Isenberg J. I. Comparison of synthetic and natural porcine secretins on human pancreatic secretion. Gastroenterology. 1974 Feb;66(2):204–209. [PubMed] [Google Scholar]
  6. Grossman M. I., Konturek S. J. Gastric acid does drive pancreatic bicarbonate secretion. Scand J Gastroenterol. 1974;9(3):299–302. [PubMed] [Google Scholar]
  7. Gutierrez L. V., Baron J. H. Maximum bicarbonate response to intravenous infusion of 'GIH' secretin in man. Clin Sci Mol Med. 1973 Dec;45(6):859–862. doi: 10.1042/cs0450859. [DOI] [PubMed] [Google Scholar]
  8. Holohan K. N., Murphy R. F., Buchanan K. D., Elmore D. T. Enzymic iodination of polypeptide hormones for radioimmunoassay. Clin Chim Acta. 1973 Apr 30;45(2):153–157. doi: 10.1016/0009-8981(73)90403-8. [DOI] [PubMed] [Google Scholar]
  9. Hubel K. A. Secretin: a long progress note. Gastroenterology. 1972 Feb;62(6):318–341. [PubMed] [Google Scholar]
  10. Konturek S. J. Pancreatic dose-response curves to intravenous secretin in man. Gastroenterology. 1970 Jun;58(6):828–832. [PubMed] [Google Scholar]
  11. Konturek S. J., Radecki T., Thor P. Comparison of endogenous release of secretin and cholecystokinin in proximal and distal duodenum in the dog. Scand J Gastroenterol. 1974;9(2):153–157. [PubMed] [Google Scholar]
  12. Lehnert P., Stahlheber H., Forell M. M., Füllner R., Frühauf S., Fritz H., Hutzel M., Werle E. Studies on the elimination of secretin and cholecystokinin with regard to the kinetics of exocrine pancreatic secretion. Digestion. 1974;11(1-2):51–63. doi: 10.1159/000197568. [DOI] [PubMed] [Google Scholar]
  13. Lehnert P., Stahlheber H., Roder O., Zoelch M., Forell M. M., Wünsch E., Jaeger E., Martens H. L. Bestimmung der biologischen Aktivität von synthetischem Secretin. Klin Wochenschr. 1973 Jan;51(1):44–46. doi: 10.1007/BF01484145. [DOI] [PubMed] [Google Scholar]
  14. Petersen H. The effect of pure natural secretin on the bicarbonate secretion into the duodenum in man. Scand J Gastroenterol. 1970;5(2):105–111. [PubMed] [Google Scholar]
  15. Polak J. M., Coulling I., Bloom S., Pearse A. G. Immunofluorescent localization of secretin and enteroglucagon in human intestinal mucosa. Scand J Gastroenterol. 1971;6(8):739–744. doi: 10.3109/00365527109179946. [DOI] [PubMed] [Google Scholar]
  16. Robinson G., Dawson I. Immunochemical studies of the endocrine cells of the gastrointestinal tract. II An immunoperoxide technique for the localization of secretin containing cells in human duodenum. J Clin Pathol. 1975 Aug;28(8):631–635. doi: 10.1136/jcp.28.8.631. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Tympner F., Domschke S., Domschke W., Classen M., Demling L. Reproducibility of the response to secretin and secretin plus pancreozymin in man. Scand J Gastroenterol. 1974;9(4):377–381. [PubMed] [Google Scholar]
  18. Vaysse N., Laval J., Duffaut M., Ribet A. Effect of secretin and graded doses of CCK-PZ on pancreatic secretion in man. Am J Dig Dis. 1974 Oct;19(10):887–894. doi: 10.1007/BF01076211. [DOI] [PubMed] [Google Scholar]
  19. Ward A. S., Bloom S. R. Effect of vagotomy on secretin release in man. Gut. 1975 Dec;16(12):951–956. doi: 10.1136/gut.16.12.951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Ward A. S., Bloom S. R. The role of secretin in the inhibition of gastric secretion by intraduodenal acid. Gut. 1974 Nov;15(11):889–897. doi: 10.1136/gut.15.11.889. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Wormsley K. G. A comparison of the response to secretin, pancreozymin and a combination of these hormones, in man. Scand J Gastroenterol. 1969;4(5):411–417. [PubMed] [Google Scholar]
  22. Wormsley K. G. Progess report. Is secretin secreted? Gut. 1973 Sep;14(9):743–751. doi: 10.1136/gut.14.9.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Wormsley K. G. Response to secretin in man. Gastroenterology. 1968 Feb;54(2):197–209. [PubMed] [Google Scholar]
  24. Wünsch E., Jaeger E., Deffner M., Scharf R., Lehnert P. Zur Synthese des Sekretins. VI. Reindarstellung des synthetischen Sekretins. Chem Ber. 1972;105(8):2515–2522. doi: 10.1002/cber.19721050811. [DOI] [PubMed] [Google Scholar]

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