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. 1977 Apr;18(4):274–278. doi: 10.1136/gut.18.4.274

Intestinal alkaline phosphatase in the diagnosis of liver disease.

T W Warnes, P Hine, G Kay
PMCID: PMC1411443  PMID: 863286

Abstract

Alkaline phosphatase isoenzymes have been studied by acrylamide gel disc electrophoresis in 76 patients with liver disorders comprising 15 with an extrahepatic lesion, 53 with an intrahepatic lesion, and eight patients who had features of both intra- and extrahepatic disease. No intestinal band was found in the 15 cases of extrahepatic liver disease, in marked contrast to the patients with intrahepatic lesions in whom an intestinal band was found in 45% of cases. The intrahepatic group was heterogeneous, a high incidence of intestinal bands being found in patients with cirrhosis of the liver. It is concluded that where a raised serum alkaline phosphatase is found in a patient with jaundice, and a gut band is present on electrophoresis, the lesion is likely to be intrahepatic.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cotton P. B. Cannulation of the papilla of Vater by endoscopy and retrograde cholangiopancreatography (ERCP). Gut. 1972 Dec;13(12):1014–1025. doi: 10.1136/gut.13.12.1014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. EVANS J. A., GLENN F., THORBJARNARSON B., MUJAHED Z. Percutaneous transhepatic cholangiography. Discussion of the method and report of 25 cases. Radiology. 1962 Mar;78:362–370. doi: 10.1148/78.3.362. [DOI] [PubMed] [Google Scholar]
  3. Elias E., Hamlyn A. N., Jain S., Long R., Summerfield J. A., Dick R., Sherlock S. Proceedings: A randomized trial of percutaneous transheptic cholangiography versus endoscopic retrograde cholangiography for bile duct visualization in cholestasis. Gut. 1975 Oct;16(10):831–831. [PubMed] [Google Scholar]
  4. FLOCK E. V., BLOCK M. A., BOLLMAN J. L., MANN F. C. Alkaline phosphate and amylase of plasma after hepatectomy. Am J Physiol. 1952 Aug;170(2):467–471. doi: 10.1152/ajplegacy.1952.170.2.467. [DOI] [PubMed] [Google Scholar]
  5. GUTMAN A. B. Serum alkaline phosphatase activity in diseases of the skeletal and hepatobiliary systems. A consideration of the current status. Am J Med. 1959 Dec;27:875–901. doi: 10.1016/0002-9343(59)90173-1. [DOI] [PubMed] [Google Scholar]
  6. James M. Normal or "negative" percutaneous cholangiogram. Arch Surg. 1971 Jul;103(1):31–33. doi: 10.1001/archsurg.1971.01350070057012. [DOI] [PubMed] [Google Scholar]
  7. KIND P. R., KING E. J. Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. J Clin Pathol. 1954 Nov;7(4):322–326. doi: 10.1136/jcp.7.4.322. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Langman M. J., Leuthold E., Robson E. B., Harris J., Luffman J. E., Harris H. Influence of diet on the "intestinal" component of serum alkaline phosphatase in people of different ABO blood groups and secretor status. Nature. 1966 Oct 1;212(5057):41–43. doi: 10.1038/212041a0. [DOI] [PubMed] [Google Scholar]
  9. Okuda K., Tanikawa K., Emura T., Kuratomi S., Jinnouchi S. Nonsurgical, percutaneous transhepatic cholangiography--diagnostic significance in medical problems of the liver. Am J Dig Dis. 1974 Jan;19(1):21–36. doi: 10.1007/BF01073350. [DOI] [PubMed] [Google Scholar]
  10. Schimmel E. M. Diagnostic procedures in liver disease. Med Clin North Am. 1968 Nov;52(6):1407–1416. [PubMed] [Google Scholar]
  11. Smith I., Lightstone P. J., Perry J. D. Separation of human tissue alkaline phosphatases by electrophoresis on acrylamide disc gels. Clin Chim Acta. 1968 Mar;19(3):499–505. doi: 10.1016/0009-8981(68)90278-7. [DOI] [PubMed] [Google Scholar]
  12. Stolbach L. L., Krant M. J., Inglis N. I., Fishman W. H. Correlation of serum L-phenylalanine-sensitive alkaline phosphatase, derived from intestine, with the ABO blood group of cirrhotics. Gastroenterology. 1967 May;52(5):819–827. [PubMed] [Google Scholar]
  13. Warnes T. W. Alkaline phosphatase. Gut. 1972 Nov;13(11):926–937. doi: 10.1136/gut.13.11.926. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Warnes T. W., Hine P., Kay G. Polyacrylamide gel disc electrophoresis of alkaline phosphatase isoenzymes in bone and liver disease. J Clin Pathol. 1976 Sep;29(9):782–787. doi: 10.1136/jcp.29.9.782. [DOI] [PMC free article] [PubMed] [Google Scholar]

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