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. 1977 May;18(5):373–376. doi: 10.1136/gut.18.5.373

Enterochromaffin cells in the duodenal mucosa of children with coeliac disease.

D N Challacombe, K Robertson
PMCID: PMC1411490  PMID: 873322

Abstract

A cell counting technique was used to count enterochromaffin (EC) cells in the duodenal mucosa of 10 children with coeliac disease and 10 controls, and significantly greater numbers of EC cells were found in children with coeliac disease. In four children with a clinical history suggestive of coeliac disease, but with minor histopathological changes in the duodenum, gluten challenge resulted in increased numbers of EC cells. Abnormalities of 5-hydroxytryptamine metabolism in coeliac disease may result from hyperplasia of EC cells in the small intestine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENSON G. D., KOWLESSAR O. D., SLEISENGER M. H. ADULT CELIAC DISEASE WITH EMPHASIS UPON RESPONSE TO THE GLUTEN-FREE DIET. Medicine (Baltimore) 1964 Jan;43:1–40. doi: 10.1097/00005792-196401000-00001. [DOI] [PubMed] [Google Scholar]
  2. Challacombe D. N., Brown G. A., Black S. C., Storrie M. H. Increased excretion of 5-hydroxyindoleacetic acid in urine of children with untreated coeliac disease. Arch Dis Child. 1972 Jun;47(253):442–445. doi: 10.1136/adc.47.253.442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Challacombe D. N., Goodall M., Gaze H., Brown G. A. Urinary 5-hydroxyindoleacetic acid in 8-hour collections as an aid in diagnosis of coeliac disease. Arch Dis Child. 1975 Oct;50(10):779–781. doi: 10.1136/adc.50.10.779. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HAVERBACK B. J., DAVIDSON J. D. Serotonin and the gastrointestinal tract. Gastroenterology. 1958 Dec;35(6):570–578. [PubMed] [Google Scholar]
  5. HAVERBACK B. J., DYCE B., THOMAS H. V. Indole metabolism in the malabsorption syndrome. N Engl J Med. 1960 Apr 14;262:754–757. doi: 10.1056/NEJM196004142621504. [DOI] [PubMed] [Google Scholar]
  6. KOWLESSAR O. D., HAEFFNER L. J., BENSON G. D. ABNORMAL TRYPTOPHAN METABOLISM IN PATIENTS WITH ADULT CELIAC DISEASE, WITH EVIDENCE FOR DEFICIENCY OF VITAMIN B6. J Clin Invest. 1964 May;43:894–903. doi: 10.1172/JCI104975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. KOWLESSAR O. D., WILLIAMS R. C., LAW D. H., SLEISENGER M. H. Urinary excretion of 5-hydroxyindolacetic acid in diarrheal states, with special reference to nontropical sprue. N Engl J Med. 1958 Aug 14;259(7):340–341. doi: 10.1056/NEJM195808142590708. [DOI] [PubMed] [Google Scholar]
  8. PIMPARKAR B. D., SENESKY D., KALSER M. H. Blood serotonin in nontropical sprue. Gastroenterology. 1961 Apr;40:504–506. [PubMed] [Google Scholar]
  9. Piris J., Whitehead R. Quantitation of G-cells in fibreoptic biopsy specimens and serum gastrin levels in healthy normal subjects. J Clin Pathol. 1975 Aug;28(8):636–638. doi: 10.1136/jcp.28.8.636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Polak J. M., Pearse A. G., Van Noorden S., Bloom S. R., Rossiter M. A. Secretin cells in coeliac disease. Gut. 1973 Nov;14(11):870–874. doi: 10.1136/gut.14.11.870. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Risdon R. A., Keeling J. W. Quantitation of the histological changes found in small intestinal biopsy specimens from children with suspected coeliac disease. Gut. 1974 Jan;15(1):9–18. doi: 10.1136/gut.15.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SCRIVER C. R. Abnormalities of tryptophan metabolism in a patient with malabsorption syndrome. J Lab Clin Med. 1961 Dec;58:908–919. [PubMed] [Google Scholar]
  13. Trier J. S., Browning T. H. Epithelial-cell renewal in cultured duodenal biopsies in celiac sprue. N Engl J Med. 1970 Dec 3;283(23):1245–1250. doi: 10.1056/NEJM197012032832302. [DOI] [PubMed] [Google Scholar]
  14. Tutton P. J. The influence of serotonin on crypt cell proliferation in the jejunum of rat. Virchows Arch B Cell Pathol. 1974;16(1):79–87. doi: 10.1007/BF02894066. [DOI] [PubMed] [Google Scholar]
  15. WEIBEL E. R. Principles and methods for the morphometric study of the lung and other organs. Lab Invest. 1963 Feb;12:131–155. [PubMed] [Google Scholar]
  16. Wright N., Watson A., Morley A., Appleton D., Marks J. Cell kinetics in flat (avillous) mucosa of the human small intestine. Gut. 1973 Sep;14(9):701–710. doi: 10.1136/gut.14.9.701. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wright N., Watson A., Morley A., Appleton D., Marks J., Douglas A. The cell cycle time in the flat (avillous) mucosa of the human small intestine. Gut. 1973 Aug;14(8):603–606. doi: 10.1136/gut.14.8.603. [DOI] [PMC free article] [PubMed] [Google Scholar]

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