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. 1977 Jun;18(6):472–475. doi: 10.1136/gut.18.6.472

Lymphocyte populations in liver biopsy specimens from patients with chronic liver disease.

J Sanchez-Tapias, H C Thomas, S Sherlock
PMCID: PMC1411515  PMID: 326639

Abstract

The characterisation of lymphocytes from liver biopsies indicates that 'activated' T lymphocytes are present in the liver in alcohol induced hepatitis, chronic active hepatitis (HBS+ve and -ve), and in primary biliary cirrhosis but not in inactive cirrhosis, chronic persistent hepatitis, extrahepatic and drug induced cholestasis. A greater percentage of lymphocytes bear Fc-receptors in chronic active hepatitis than in alcohol induced hepatitis or cholestatic liver disease. The concentration of 'activated' T cells in the peripheral blood in all groups studied was within the normal range, suggesting that the 'activated' T cells found in the liver were reacting to either native or foreign antigens within the liver. The data on Fc-receptor bearing cells are consistent with the involvement of antibody assisted K cell mediated cytotoxicity in chronic active hepatitis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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