Abstract
Experiments on dogs and rats showed that synthetic human gastrin I was inactivated in the small bowel but not in the liver, whereas pentagastrin was rapidly inactivated by the liver. Similar results were obtained with tissue homogenates. The significance of these results is discussed in relation to the probably increased incidence of peptic ulceration following extensive small-bowel resection in man.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Elliott T. R. The action of adrenalin. J Physiol. 1905 Jul 13;32(5-6):401–467. doi: 10.1113/jphysiol.1905.sp001093. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GILLESPIE I. E., GROSSMAN M. I. Gastric secretion of acid in response to portal and systemic venous injection of gastrin. Gastroenterology. 1962 Aug;43:189–192. [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- McGuigan J. E., Jaffe B. M., Newton W. T. Immunochemical measurements of endogenous gastrin release. Gastroenterology. 1970 Oct;59(4):499–505. [PubMed] [Google Scholar]
- Morley J. S., Tracy H. J., Gregory R. A. Structure-function relationships in the active C-terminal tetrapeptide sequence of gastrin. Nature. 1965 Sep 25;207(5004):1356–1359. doi: 10.1038/2071356a0. [DOI] [PubMed] [Google Scholar]
- Osborne M. P., Frederick P. L., Sizer J. S., Blair D., Cole P., Thum W. Mechanism of gastric hypersecretion following massive intestinal resection. Clinical and experimental observations. Ann Surg. 1966 Oct;164(4):622–634. doi: 10.1097/00000658-196610000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith G. M., Lawrence A. J., Colin-Jones D. G., Schild H. O. The assay of gastrin using the perfused rat stomach. Br J Pharmacol. 1970 Jan;38(1):206–213. [PMC free article] [PubMed] [Google Scholar]
- Thompson J. C., Reeder D. D., Davidson W. D., Charters A. C., Brückner W. L., Lemmi C. A., Miller J. H. Effect of hepatic transit of gastrin, pentagastrin, and histamine measured by gastric secretion and by assay of hepatic vein blood. Ann Surg. 1969 Sep;170(3):493–505. doi: 10.1097/00000658-196909010-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]