Skip to main content
PMC home page
Gut logoLink to Gut
. 1971 Jun;12(6):445–448. doi: 10.1136/gut.12.6.445

Changes in structure and peptidase activity of rat small intestine induced by prednisolone

Alfred J Wall, T J Peters
PMCID: PMC1411659  PMID: 5090868

Abstract

Chronic dietary administration of prednisolone to the adult rat caused alteration in morphology and enzyme activity of the small intestinal mucosa. Reduction of villous height, crypt depth, and surface epithelial cell height was accompanied by a significant increase in the specific activity of several jejunal peptidases.

Full text

PDF
448

Images in this article

446Fig. 1
on p.446

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BUCHER N. L. REGENERATION OF MAMMALIAN LIVER. Int Rev Cytol. 1963;15:245–300. doi: 10.1016/s0074-7696(08)61119-5. [DOI] [PubMed] [Google Scholar]
  2. Bellamy D., Leonard R. A. The action of corticosteroids on proteolysis. Biochem J. 1966 Feb;98(2):581–586. doi: 10.1042/bj0980581. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FRAZER A. C. On the growth defect in coelic disease. Proc R Soc Med. 1956 Dec;49(12):1009–1013. [PMC free article] [PubMed] [Google Scholar]
  4. GOLDBARG J. A., RUTENBURG A. M. The colorimetric determination of leucine aminopeptidase in urine and serum of normal subjects and patients with cancer and other diseases. Cancer. 1958 Mar-Apr;11(2):283–291. doi: 10.1002/1097-0142(195803/04)11:2<283::aid-cncr2820110209>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  5. HECHTER O., HALKERSTON I. D. EFFECTS OF STEROID HORMONES ON GENE REGULATION AND CELL METABOLISM. Annu Rev Physiol. 1965;27:133–162. doi: 10.1146/annurev.ph.27.030165.001025. [DOI] [PubMed] [Google Scholar]
  6. Hoffbrand A. V., Peters T. J. The subcellular localization of pteroyl polyglutamate hydrolase and folate in guinea pig intestinal mucosa. Biochim Biophys Acta. 1969 Dec 30;192(3):479–485. doi: 10.1016/0304-4165(69)90397-3. [DOI] [PubMed] [Google Scholar]
  7. IZZO J. L., GLASSER S. R. Comparative effects of glucagon, hydrocortisone and epinephrine on the protein metabolism of the fasting rat. Endocrinology. 1961 Feb;68:189–198. doi: 10.1210/endo-68-2-189. [DOI] [PubMed] [Google Scholar]
  8. LENARD J., JOHNSON S. L., HYMAN R. W., HESS G. P. A CONTINUOUS, AUTOMATIC METHOD FOR THE STUDY OF RATE OF HYDROLYSIS OF PEPTIDES AND AMIDES. Anal Biochem. 1965 Apr;11:30–41. doi: 10.1016/0003-2697(65)90039-4. [DOI] [PubMed] [Google Scholar]
  9. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  10. Moog F., Grey R. D. Alkaline phosphatase isozymes in the duodenum of the mouse: attainment of pattern of spatial distribution in normal development and under the influence of cortisone or actinomycin D. Dev Biol. 1968 Nov;18(5):481–500. doi: 10.1016/0012-1606(68)90053-5. [DOI] [PubMed] [Google Scholar]
  11. PINA E., HAMABATA A., LAGUNA J. Effect of low concentration of steroids on the activity of glycylglycine dipeptidase in vitro. Biochem Biophys Res Commun. 1962 Nov 27;9:447–450. doi: 10.1016/0006-291x(62)90032-3. [DOI] [PubMed] [Google Scholar]
  12. ROY A. B. The sulphatase of ox liver. I. The complex nature of the enzyme. Biochem J. 1953 Jan;53(1):12–15. doi: 10.1042/bj0530012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ragins H., Wincze F. Effect of cortisone on the turnover of gastric parietal cells in the mouse. Endocrinology. 1969 Jan;84(1):83–90. doi: 10.1210/endo-84-1-83. [DOI] [PubMed] [Google Scholar]
  14. SCHWARTZ T. B., ROBERTSON M. C., HOLMES L. B. Adrenocortical influences on dipeptidase activity of surviving rat diaphragm. Endocrinology. 1956 Apr;58(4):453–460. doi: 10.1210/endo-58-4-453. [DOI] [PubMed] [Google Scholar]
  15. TALANTI S., HOPSU V. K. Leucine aminopeptidase in the gastric muscosa of the adrenalectomized rat. Endocrinology. 1961 Jan;68:184–185. doi: 10.1210/endo-68-1-184. [DOI] [PubMed] [Google Scholar]
  16. Wall A. J., Douglas A. P., Booth C. C., Pearse A. G. Response of the jejunal mucosa in adult coeliac disease to oral prednisolone. Gut. 1970 Jan;11(1):7–14. doi: 10.1136/gut.11.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES