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. 1977 Nov;18(11):882–886. doi: 10.1136/gut.18.11.882

Increased tissue concentrations of 5-hydroxytryptamine in the duodenal mucosa of patients with coeliac disease.

D N Challacombe, P D Dawkins, P Baker
PMCID: PMC1411730  PMID: 590848

Abstract

Tissue concentrations of 5-HT have been measured in the duodenal mucosa of adults and children with coeliac disease and were found to be significantly higher than those from a control group. This finding may be associated with hyperactivity or hyperplasia of enterochromaffin (EC) cells in the duodenum of patients with coeliac disease and could also be directly related to described abnormalities of 5-HT metabolism in this disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENSON G. D., KOWLESSAR O. D., SLEISENGER M. H. ADULT CELIAC DISEASE WITH EMPHASIS UPON RESPONSE TO THE GLUTEN-FREE DIET. Medicine (Baltimore) 1964 Jan;43:1–40. doi: 10.1097/00005792-196401000-00001. [DOI] [PubMed] [Google Scholar]
  2. Challacombe D. N., Brown G. A., Black S. C., Storrie M. H. Increased excretion of 5-hydroxyindoleacetic acid in urine of children with untreated coeliac disease. Arch Dis Child. 1972 Jun;47(253):442–445. doi: 10.1136/adc.47.253.442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Challacombe D. N., Goodall M., Gaze H., Brown G. A. Urinary 5-hydroxyindoleacetic acid in 8-hour collections as an aid in diagnosis of coeliac disease. Arch Dis Child. 1975 Oct;50(10):779–781. doi: 10.1136/adc.50.10.779. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Challacombe D. N., Robertson K. Enterochromaffin cells in the duodenal mucosa of children with coeliac disease. Gut. 1977 May;18(5):373–376. doi: 10.1136/gut.18.5.373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Challacombe D. N., Sandler M., Southgate J. Decreased duodenal monoamine oxidase activity in coeliac disease. Arch Dis Child. 1971 Apr;46(246):213–215. doi: 10.1136/adc.46.246.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Curzon G., Green A. R. Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain. Br J Pharmacol. 1970 Jul;39(3):653–655. doi: 10.1111/j.1476-5381.1970.tb10373.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HAVERBACK B. J., DAVIDSON J. D. Serotonin and the gastrointestinal tract. Gastroenterology. 1958 Dec;35(6):570–578. [PubMed] [Google Scholar]
  8. HAVERBACK B. J., DYCE B., THOMAS H. V. Indole metabolism in the malabsorption syndrome. N Engl J Med. 1960 Apr 14;262:754–757. doi: 10.1056/NEJM196004142621504. [DOI] [PubMed] [Google Scholar]
  9. KOWLESSAR O. D., HAEFFNER L. J., BENSON G. D. ABNORMAL TRYPTOPHAN METABOLISM IN PATIENTS WITH ADULT CELIAC DISEASE, WITH EVIDENCE FOR DEFICIENCY OF VITAMIN B6. J Clin Invest. 1964 May;43:894–903. doi: 10.1172/JCI104975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  11. PIMPARKAR B. D., SENESKY D., KALSER M. H. Blood serotonin in nontropical sprue. Gastroenterology. 1961 Apr;40:504–506. [PubMed] [Google Scholar]
  12. SCRIVER C. R. Abnormalities of tryptophan metabolism in a patient with malabsorption syndrome. J Lab Clin Med. 1961 Dec;58:908–919. [PubMed] [Google Scholar]
  13. Small N. A., Holton J. B. Determination of platelet serotonin by a fluorimetric method. Clin Chim Acta. 1970 Jan;27(1):171–175. doi: 10.1016/0009-8981(70)90392-x. [DOI] [PubMed] [Google Scholar]
  14. Snyder S. H., Axelrod J., Zweig M. A sensitive and specific fluorescence assay for tissue serotonin. Biochem Pharmacol. 1965 May;14(5):831–835. doi: 10.1016/0006-2952(65)90102-4. [DOI] [PubMed] [Google Scholar]
  15. Trier J. S., Browning T. H. Epithelial-cell renewal in cultured duodenal biopsies in celiac sprue. N Engl J Med. 1970 Dec 3;283(23):1245–1250. doi: 10.1056/NEJM197012032832302. [DOI] [PubMed] [Google Scholar]
  16. Tutton P. J. The influence of serotonin on crypt cell proliferation in the jejunum of rat. Virchows Arch B Cell Pathol. 1974;16(1):79–87. doi: 10.1007/BF02894066. [DOI] [PubMed] [Google Scholar]
  17. WARNER R. R., COHEN N. Blood serotonin in malabsorption states. Am J Dig Dis. 1962 Jun;7:553–556. doi: 10.1007/BF02236135. [DOI] [PubMed] [Google Scholar]
  18. Wright N., Watson A., Morley A., Appleton D., Marks J. Cell kinetics in flat (avillous) mucosa of the human small intestine. Gut. 1973 Sep;14(9):701–710. doi: 10.1136/gut.14.9.701. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Wright N., Watson A., Morley A., Appleton D., Marks J., Douglas A. The cell cycle time in the flat (avillous) mucosa of the human small intestine. Gut. 1973 Aug;14(8):603–606. doi: 10.1136/gut.14.8.603. [DOI] [PMC free article] [PubMed] [Google Scholar]

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