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. 1971 Jul;12(7):552–558. doi: 10.1136/gut.12.7.552

The effect of healing on bile reflux in gastric ulcer

R B Black, Gwenda Roberts, J Rhodes
PMCID: PMC1411867  PMID: 5559144

Abstract

Bile reflux has been studied by serial estimations of bile acid concentrations in the stomach before and after a liquid meal. Thirteen normal subjects and 38 patients with gastric ulcer were examined. Thirty-one in the ulcer group had the test repeated once or twice within two months of the initial test to observe any change in reflux associated with healing. Patients with gastric ulcer had significantly higher concentrations of bile acids than normal subjects, both before and after the meal, although there was an overlap between the groups. In patients with an ulcer which healed or showed some healing over two months, no consistent change in reflux was found.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BORTH R. Steroids in human blood. Vitam Horm. 1957;15:259–290. doi: 10.1016/s0083-6729(08)60512-9. [DOI] [PubMed] [Google Scholar]
  2. Capper W. M. Factors in the pathogenesis of gastric ulcer. Hunterian lecture delivered at the Royal College of Surgeons of England on 18th January 1966. Ann R Coll Surg Engl. 1967 Jan;40(1):21–35. [PMC free article] [PubMed] [Google Scholar]
  3. DU PLESSIS D. J. Some aspects of the pathogenesis and surgical management of peptic ulcers. S Afr Med J. 1960 Feb 6;34:101–108. [PubMed] [Google Scholar]
  4. DUPLESSIS D. J. PATHOGENESIS OF GASTRIC ULCERATION. Lancet. 1965 May 8;1(7393):974–978. doi: 10.1016/s0140-6736(65)91214-6. [DOI] [PubMed] [Google Scholar]
  5. Davenport H. W. Destruction of the gastric mucosal barrier by detergents and urea. Gastroenterology. 1968 Feb;54(2):175–181. [PubMed] [Google Scholar]
  6. Davenport H. W. The proper study. Gastroenterology. 1970 Apr;58(4):590–591. [PubMed] [Google Scholar]
  7. Garrett J. M., Summerskill W. H., Code C. F. Antral motility in patients with gastric ulcer. Am J Dig Dis. 1966 Oct;11(10):780–789. doi: 10.1007/BF02233838. [DOI] [PubMed] [Google Scholar]
  8. Hofmann A. F., Small D. M. Detergent properties of bile salts: correlation with physiological function. Annu Rev Med. 1967;18:333–376. doi: 10.1146/annurev.me.18.020167.002001. [DOI] [PubMed] [Google Scholar]
  9. IWATA T., YAMASAKI K. ENZYMATIC DETERMINATION AND THIN-LAYER CHROMATOGRAPHY OF BILE ACIDS IN BLOOD. J Biochem. 1964 Nov;56:424–431. doi: 10.1093/oxfordjournals.jbchem.a128013. [DOI] [PubMed] [Google Scholar]
  10. Kirk R. M. Experimental gastric ulcers in the rat: the separate and combined effects of vagotomy and bile-duct implantation into the stomach. Br J Surg. 1970 Jul;57(7):521–524. doi: 10.1002/bjs.1800570710. [DOI] [PubMed] [Google Scholar]
  11. LAWSON H. H. EFFECT OF DUODENAL CONTENTS ON THE GASTRIC MUCOSA UNDER EXPERIMENTAL CONDITIONS. Lancet. 1964 Feb 29;1(7331):469–472. doi: 10.1016/s0140-6736(64)90800-1. [DOI] [PubMed] [Google Scholar]
  12. MICHAUELSSON M., NOSSLIN B., SJOELIN S. PLASMA BILIRUBIN DETERMINATION IN THE NEWBORN INFANT. A METHODOLOGICAL STUDY WITH SPECIAL REFERENCE TO THE INFLUENCE OF HEMOLYSIS. Pediatrics. 1965 Jun;35:925–931. [PubMed] [Google Scholar]
  13. Rhodes J., Barnardo D. E., Phillips S. F., Rovelstad R. A., Hofmann A. F. Increased reflux of bile into the stomach in patients with gastric ulcer. Gastroenterology. 1969 Sep;57(3):241–252. [PubMed] [Google Scholar]
  14. Turnberg L. A., Anthony-Mote A. The quantitative determination of bile salts in bile using thin-layer chromatography and 3 alpha-hydroxysteroid dehydrogenase. Clin Chim Acta. 1969 May;24(2):253–259. doi: 10.1016/0009-8981(69)90321-0. [DOI] [PubMed] [Google Scholar]
  15. WATKINSON G. A study of the changes in pH of gastric contents in peptic ulcer using the twenty-four hour test meal. Gastroenterology. 1951 Jul;18(3):377–390. [PubMed] [Google Scholar]

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