Skip to main content
PMC home page
Gut logoLink to Gut
. 1971 Oct;12(10):773–782. doi: 10.1136/gut.12.10.773

Endocrine tumour in kidney affecting small bowel structure, motility, and absorptive function 1

M H Gleeson, S R Bloom, J M Polak, K Henry, R H Dowling
PMCID: PMC1411871  PMID: 4941684

Abstract

A 44-year-old woman is described with an endocrine tumour arising in the kidney. There were associated abnormalities of small intestinal morphology, motility, and absorptive function. These abnormalities reversed on removal of the tumour. Detailed studies showed that the tumour contained, and was secreting, glucagon. It is postulated that the intestinal abnormalities may have resulted from glucagon itself or another, as yet unidentified, hormone.

Full text

PDF
775

Images in this article

776Fig. 1
on p.776
776Fig. 2
on p.776
777Fig. 3
on p.777
778Fig. 4
on p.778
778Fig. 5
on p.778
779Fig. 6
on p.779

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOOTH C. C., EVANS K. T., MENZIES T., STREET D. F. Intestinal hypertrophy following partial resection of the small bowel in the rat. Br J Surg. 1959 Jan;46(198):403–410. doi: 10.1002/bjs.18004619821. [DOI] [PubMed] [Google Scholar]
  2. COONS A. H., LEDUC E. H., CONNOLLY J. M. Studies on antibody production. I. A method for the histochemical demonstration of specific antibody and its application to a study of the hyperimmune rabbit. J Exp Med. 1955 Jul 1;102(1):49–60. doi: 10.1084/jem.102.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CURZON G., WALSH J. A method for the determination of urinary indoxyl sulphate (indican). Clin Chim Acta. 1962 Sep;7:657–663. doi: 10.1016/0009-8981(62)90147-x. [DOI] [PubMed] [Google Scholar]
  4. Dowling R. H., Booth C. C. Structural and functional changes following small intestinal resection in the rat. Clin Sci. 1967 Feb;32(1):139–149. [PubMed] [Google Scholar]
  5. Dyck W. P., Texter E. C., Jr, Lasater J. M., Hightower N. C., Jr Influence of glucagon on pancreatic exocrine secretion in man. Gastroenterology. 1970 Apr;58(4):532–539. [PubMed] [Google Scholar]
  6. GOESSNER W., KORTING G. W. [Metastasizing islet cell carcinoma of the A cell type in a case of pemphigus foliaceus with diabetes renalis]. Dtsch Med Wochenschr. 1960 Mar 1;85:434–437. doi: 10.1055/s-0028-1112452. [DOI] [PubMed] [Google Scholar]
  7. Helmer O. M., Fouts P. J. GASTRO-INTESTINAL STUDIES. VII. THE EXCRETION OF XYLOSE IN PERNICIOUS ANEMIA. J Clin Invest. 1937 May;16(3):343–349. doi: 10.1172/JCI100862. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kock N. G., Darle N., Dotevall G. Inhibition of intestinal motility in man by glucagon given intraportally. Gastroenterology. 1967 Jul;53(1):88–92. [PubMed] [Google Scholar]
  9. Kock N. G., Tibblin S., Schenk W. G., Jr Hemodynamic responses to glucagon: an experimental study of central, visceral and peripheral effects. Ann Surg. 1970 Mar;171(3):373–379. doi: 10.1097/00000658-197003000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LORAN M. R., ALTHAUSEN T. L. Cellular proliferation of intestinal epithelia in the rat two months after partial resection of the ileum. J Biophys Biochem Cytol. 1960 Jul;7:667–672. doi: 10.1083/jcb.7.4.667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. LORAN M. R., CROCKER T. T. POPULATION DYNAMICS OF INTESTINAL EPITHELIA IN THE RAT TWO MONTHS AFTER PARTIAL RESECTION OF THE ILEUM. J Cell Biol. 1963 Nov;19:285–291. doi: 10.1083/jcb.19.2.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. McGavran M. H., Unger R. H., Recant L., Polk H. C., Kilo C., Levin M. E. A glucagon-secreting alpha-cell carcinoma of the pancreas. N Engl J Med. 1966 Jun 23;274(25):1408–1413. doi: 10.1056/NEJM196606232742503. [DOI] [PubMed] [Google Scholar]
  13. Neale G., Lambert R. A., Gorbach S. The production of indole by bacteria in vitro. Gut. 1969 Dec;10(12):1056–1057. [PubMed] [Google Scholar]
  14. Pearse A. G. The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J Histochem Cytochem. 1969 May;17(5):303–313. doi: 10.1177/17.5.303. [DOI] [PubMed] [Google Scholar]
  15. Polak J. M., Bloom S., Coulling I., Pearse A. G. Immunofluorescent localization of enteroglucagon cells in the gastrointestinal tract of the dog. Gut. 1971 Apr;12(4):311–318. doi: 10.1136/gut.12.4.311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Polak J. M., Doe W., Coulling I., Pearse A. G. The G cells in pernicious anaemia. Gut. 1971 Apr;12(4):319–323. doi: 10.1136/gut.12.4.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Rost F. W., Polak J. M., Pearse A. G. The melanocyte: its cytochemical and immunological relationship to cells of the endocrine polypeptide (APUD) series. Virchows Arch B Cell Pathol. 1969;4(2):93–101. doi: 10.1007/BF02906064. [DOI] [PubMed] [Google Scholar]
  18. SCHILLING R. F. Intrinsic factor studies II. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12. J Lab Clin Med. 1953 Dec;42(6):860–866. [PubMed] [Google Scholar]
  19. Solcia E., Sampietro R., Capella C. Differential staining of catecholamines, 5-hydroxytryptamine and related compounds in aldehyde-fixed tissues. Histochemie. 1969;17(3):273–283. doi: 10.1007/BF00309872. [DOI] [PubMed] [Google Scholar]
  20. UNGER R. H., LOCHNERJDE V., EISENTRAUT A. M. IDENTIFICATION OF INSULIN AND GLUGACON IN A BRONCHOGENIC METASTASIS. J Clin Endocrinol Metab. 1964 Sep;24:823–831. doi: 10.1210/jcem-24-9-823. [DOI] [PubMed] [Google Scholar]
  21. Vance J. E., Kitabchi A. E., Buchanan K. D., Stoli R. W., Hollander D., Wood F. C., Jr Hypersecretion of insulin, glucagon and gastrin in a kindred with multiple adenomatosis. Diabetes. 1968;17:299–299. [PubMed] [Google Scholar]
  22. Yoshinaga T., Okuno G., Shinji Y., Tsujii T., Nishikawa M. Pancreatic A-cell tumor associated with severe diabetes mellitus. Diabetes. 1966 Oct;15(10):709–713. doi: 10.2337/diab.15.10.709. [DOI] [PubMed] [Google Scholar]
  23. van Tongeren J. H., Majoor C. L. Demonstration of protein-losing gastroenteropathy. The disappearance rate of 51Cr from plasma and the binding of 51Cr to different serum proteins. Clin Chim Acta. 1966 Jul;14(1):31–41. doi: 10.1016/0009-8981(66)90061-1. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES