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. 1978 Mar;19(3):170–174. doi: 10.1136/gut.19.3.170

Serum prolactin in liver disease and its relationship to gynaecomastia.

M Y Morgan, A W Jakobovits, M B Gore, M R Wills, S Sherlock
PMCID: PMC1411915  PMID: 631637

Abstract

Serum immunoreactive prolactin was measured in 150 patients with liver disease of varying aetiology and severity and in 45 control subjects. The upper limit of the reference range for serum prolactin was 331 mU/l. Eighteen patients with liver disease (12%) had unexplained hyperprolactinaemia. No relationship existed between the prolactin value and the sex of the patient, the aetiology of the liver disease, the severity of the liver disease, or the presence of gynaecomastia. The cause of the hyperprolactinaemia in patients with liver disease and its clinical implications need further investigation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adlercreutz H. Hepatic metabolism of estrogens in health and disease. N Engl J Med. 1974 May 9;290(19):1081–1083. doi: 10.1056/NEJM197405092901913. [DOI] [PubMed] [Google Scholar]
  2. Cole E. N., Boyns A. R. Radioimmunoassay for human pituitary prolactin, using antiserum against an extract of human amniotic fluid. Horm Res. 1973;4(5):261–273. doi: 10.1159/000178313. [DOI] [PubMed] [Google Scholar]
  3. Green J. R., Mowat N. A., Fisher R. A., Anderson D. C. Plasma oestrogens in men with chronic liver disease. Gut. 1976 Jun;17(6):426–430. doi: 10.1136/gut.17.6.426. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. SUMMERSKILL W. H., DAVIDSON C. S., DIBLE J. H., MALLORY G. K., SHERLOCK S., TURNER M. D., WOLFE S. J. Cirrhosis of the liver: a study of alcoholic and nonalcoholic patients in Boston and London. N Engl J Med. 1960 Jan 7;262:1–9. doi: 10.1056/NEJM196001072620101. [DOI] [PubMed] [Google Scholar]
  5. Turkington R. W. Serum prolactin levels in patients with gynecomastia. J Clin Endocrinol Metab. 1972 Jan;34(1):62–66. doi: 10.1210/jcem-34-1-62. [DOI] [PubMed] [Google Scholar]
  6. Van Thiel D. H., Gavaler J. S., Lester R., Loriaux D. L., Braunstein G. D. Plasma estrone, prolactin, neurophysin, and sex steroid-binding globulin in chronic alcoholic men. Metabolism. 1975 Sep;24(9):1015–1019. doi: 10.1016/0026-0495(75)90094-3. [DOI] [PubMed] [Google Scholar]
  7. Van Thiel D. H., Lester R. Alcoholism: its effect on hypothalamic pituitary gonadal function. Gastroenterology. 1976 Aug;71(2):318–327. [PubMed] [Google Scholar]
  8. Van Thiel D. H., Lester R. Editorial: Sex and alcohol. N Engl J Med. 1974 Aug 1;291(5):251–253. doi: 10.1056/NEJM197408012910511. [DOI] [PubMed] [Google Scholar]
  9. Van Thiel D. H., Lester R., Sherins R. J. Hypogonadism in alcoholic liver disease: evidence for a double defect. Gastroenterology. 1974 Dec;67(6):1188–1199. [PubMed] [Google Scholar]
  10. Wernze H., Schmitz E. Plasma prolactin and prolactin release in liver cirrhosis. Acta Hepatogastroenterol (Stuttg) 1977 Apr;24(2):97–101. [PubMed] [Google Scholar]
  11. Wiedemann E., Schwartz E., Frantz A. G. Acute and chronic estrogen effects upon serum somatomedin activity, growth hormone, and prolactin in man. J Clin Endocrinol Metab. 1976 May;42(5):942–952. doi: 10.1210/jcem-42-5-942. [DOI] [PubMed] [Google Scholar]
  12. Yen S. S., Ehara Y., Siler T. M. Augmentation of prolactin secretion by estrogen in hypogonadal women. J Clin Invest. 1974 Feb;53(2):652–655. doi: 10.1172/JCI107600. [DOI] [PMC free article] [PubMed] [Google Scholar]

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