Skip to main content
Gut logoLink to Gut
. 1972 Jan;13(1):39–42. doi: 10.1136/gut.13.1.39

Serum gastrin in duodenal ulcer

Part III Influence of vagotomy and pylorectomy

M G Korman, J Hansky, P R Scott
PMCID: PMC1411980  PMID: 5060667

Abstract

Following truncal vagotomy and anterior pylorectomy for duodenal ulcer, fasting serum gastrin levels were higher at 84 ± 7·9 pg per ml than in unoperated patients with duodenal ulcer (16 ± 1·5 pg per ml). In response to a standard protein meal, the peak serum gastrin achieved in the vagotomized group was 259 ± 37·8 pg per ml at 75 minutes after ingestion, a much higher response than that obtained with a standard meal plus prior atropinization in the unoperated duodenal ulcer patients.

These results suggest that truncal vagotomy allows release of gastrin which was previously inhibited with the vagi intact and the temporal characteristics of the response indicate that some of this gastrin is derived from an extragastric source. The results also exemplify the dependence of gastrin estimations as measured by this immunoassay on the acidity of the contents bathing the gastric antrum.

Full text

PDF
42

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berson S. A., Yllow R. S. Nature of immunoreactive gastrin extracted from tissues of gastrointestinal tract. Gastroenterology. 1971 Feb;60(2):215–222. [PubMed] [Google Scholar]
  2. Byrnes D. J., Lazarus L., Young J. D. Effect of vagotomy on serum gastrin in patients with duodenal ulceration. Australas Ann Med. 1970 Aug;19(3):240–243. doi: 10.1111/imj.1970.19.3.240. [DOI] [PubMed] [Google Scholar]
  3. Emås S., Borg I., Fyrö B. Antral and duodenal gastrin activity in non-ulcer and ulcer patients. Scand J Gastroenterol. 1971;6(1):39–43. doi: 10.3109/00365527109180667. [DOI] [PubMed] [Google Scholar]
  4. Emås S., Grossman M. I. Response of Heidenhain pouch to histamine, gastrin and feeding before and after truncal vagotomy in dogs. Scand J Gastroenterol. 1969;4(6):497–503. doi: 10.3109/00365526909180640. [DOI] [PubMed] [Google Scholar]
  5. Hansky J., Cain M. D. Radioimmunoassay of gastrin in human serum. Lancet. 1969 Dec 27;2(7635):1388–1390. doi: 10.1016/s0140-6736(69)90933-7. [DOI] [PubMed] [Google Scholar]
  6. Hansky J., Korman M. G., Cowley D. J., Baron J. H. Serum gastrin in duodenal ulcer. II. Effect of insulin hypoglycaemia. Gut. 1971 Dec;12(12):959–962. doi: 10.1136/gut.12.12.959. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hansky J., Soveny C., Korman M. G. Effect of secretin on serum gastrin as measured by immunoassay. Gastroenterology. 1971 Jul;61(1):62–68. [PubMed] [Google Scholar]
  8. KELLY K. A., NYHUS L. M., HARKINS H. N. THE VAGAL NERVE AND THE INTESTINAL PHASE OF GASTRIC SECRETION. Gastroenterology. 1964 Feb;46:163–166. [PubMed] [Google Scholar]
  9. Korman M. G., Soveny C., Hansky J. Radioimmunoassay of gastrin. The response of serum gastrin to insulin hypoglycaemia. Scand J Gastroenterol. 1971;6(1):71–75. doi: 10.3109/00365527109180673. [DOI] [PubMed] [Google Scholar]
  10. Korman M. G., Soveny C., Hansky J. Serum gastrin in duodenal ulcer. I. Basal levels and effect of food and atropine. Gut. 1971 Nov;12(11):899–902. doi: 10.1136/gut.12.11.899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Korman M. G., Strickland R. G., Hansky J. Serum gastrin in chronic gastritis. Br Med J. 1971 Apr 3;2(5752):16–18. doi: 10.1136/bmj.2.5752.16. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. LANDOR J. H. THE EFFECT OF EXTRAGASTRIC VAGOTOMY ON HEIDENHAIN-POUCH SECRETION IN DOGS. Am J Dig Dis. 1964 Apr;9:256–262. doi: 10.1007/BF02232130. [DOI] [PubMed] [Google Scholar]
  13. Middleton M. D., Kelly K. A., Nyhus L. M., Harkins H. N. Selective vagal effects on the intestinal phase of gastric secretion. Gut. 1965 Jun;6(3):296–300. doi: 10.1136/gut.6.3.296. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. PEVSNER L., GROSSMAN M. I. The mechanism of vagal stimulation of gastric acid secretion. Gastroenterology. 1955 Apr;28(4):493-9; discussion, 531-5. [PubMed] [Google Scholar]
  15. Posey E. L., Jr, Franklin H. Relation of antral pH to gastrin release and fundal pH in dogs. Am J Dig Dis. 1967 Apr;12(4):356–362. doi: 10.1007/BF02241937. [DOI] [PubMed] [Google Scholar]
  16. Scott P. R. Vagotomy and anterior pylorectomy for uncomplicated duodneal ulceration: results of 38 cases. Aust N Z J Surg. 1968 Nov;38(2):141–143. [PubMed] [Google Scholar]
  17. Stening G. F., Grossman M. I. Gastric acid response to pentagastrin and histamine after extragastric vagotomy in dogs. Gastroenterology. 1970 Sep;59(3):364–371. [PubMed] [Google Scholar]
  18. Thein M. P., Schofield B. Release of gastrin from the pyloric antrum following vagal stimulation by sham feeding in dogs. J Physiol. 1959 Oct;148(2):291–305. doi: 10.1113/jphysiol.1959.sp006289. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES