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. 1972 Feb;13(2):112–123. doi: 10.1136/gut.13.2.112

Coeliac disease, vasculitis, and cryoglobulinaemia

William F Doe, D Evans, J R Hobbs, C C Booth
PMCID: PMC1412064  PMID: 4625658

Abstract

Four patients are described with the association of adult coeliac disease, vasculitis, and cryoglobulinaemia. In each patient the cryoglobulinaemia was of the mixed type consisting of more than one immunoglobulin class. It is suggested that the mixed cryoglobulins represent circulating immune complexes and that their deposition in small vessels causes the vasculitis. This is supported by immunofluorescent studies of skin biopsies from one of these patients. The significance of these findings in the four adult coeliac patients is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROMBERG-SZNEK S., MULLER J. Experiments on the mechanism of precipitation of cryoglobulins. Acta Med Scand. 1961 Sep;170:277–285. doi: 10.1111/j.0954-6820.1961.tb00240.x. [DOI] [PubMed] [Google Scholar]
  2. Booth C. C. The enterocyte in coeliac disease. Br Med J. 1970 Oct 3;4(5726):14–17. doi: 10.1136/bmj.4.5726.14. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HOURIHANE D. O. DIARRHOEA OF SMALL BOWEL ORIGIN. THE HISTOLOGY OF INTESTINAL BIOPSIES. Proc R Soc Med. 1963 Dec;56:1073–1077. [PMC free article] [PubMed] [Google Scholar]
  4. Hobbs J. R., Hepner G. W., Douglas A. P., Crabbé P. A., Johansson S. G. Immunological mystery of coeliac disease. Lancet. 1969 Sep 20;2(7621):649–650. doi: 10.1016/s0140-6736(69)90362-6. [DOI] [PubMed] [Google Scholar]
  5. KOHNER E., GREENBERG G. FUNDAL LESIONS IN SARCOIDOSIS. Postgrad Med J. 1964 Dec;40:717–719. doi: 10.1136/pgmj.40.470.717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Katz J., Kantor F. S., Herskovic T. Intestinal antibodies to wheat fractions in celiac disease. Ann Intern Med. 1968 Dec;69(6):1149–1153. doi: 10.7326/0003-4819-69-6-1149. [DOI] [PubMed] [Google Scholar]
  7. LAURELL C. B. ANTIGEN-ANTIBODY CROSSED ELECTROPHORESIS. Anal Biochem. 1965 Feb;10:358–361. doi: 10.1016/0003-2697(65)90278-2. [DOI] [PubMed] [Google Scholar]
  8. LOSPALLUTO J., DORWARD B., MILLER W., Jr, ZIFF M. Cryoglobulinemia based on interaction between a gamma macroglobulin and 7S gamma globulin. Am J Med. 1962 Jan;32:142–147. doi: 10.1016/0002-9343(62)90191-2. [DOI] [PubMed] [Google Scholar]
  9. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  10. Meltzer M., Franklin E. C. Cryoglobulins, rheumatoid factors and connective tissue disorders. Arthritis Rheum. 1967 Oct;10(5):489–492. doi: 10.1002/art.1780100513. [DOI] [PubMed] [Google Scholar]
  11. Meltzer M., Franklin E. C., Elias K., McCluskey R. T., Cooper N. Cryoglobulinemia--a clinical and laboratory study. II. Cryoglobulins with rheumatoid factor activity. Am J Med. 1966 Jun;40(6):837–856. doi: 10.1016/0002-9343(66)90200-2. [DOI] [PubMed] [Google Scholar]
  12. Melvin K. E., Hepner G. W., Bordier P., Neale G., Joplin G. F. Calcium metabolism and bone pathology in adult coeliac disease. Q J Med. 1970 Jan;39(153):83–113. [PubMed] [Google Scholar]
  13. OUCHTERLONY O. Diffusion-in-gel methods for immunological analysis. Prog Allergy. 1958;5:1–78. [PubMed] [Google Scholar]
  14. PLOTZ C. M., SINGER J. M. The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis. Am J Med. 1956 Dec;21(6):888–892. [PubMed] [Google Scholar]
  15. RUBIN W., FAUCI A. S., MARVIN S. F., SLEISENGER M. H., JEFRIES G. H. IMMUNOFLUORESCENT STUDIES IN ADULT CELIAC DISEASE. J Clin Invest. 1965 Mar;44:475–485. doi: 10.1172/JCI105161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Riethmüller G., Meltzer M., Franklin E., Miescher P. A. Serum complement levels in patients with mixed (IgM-IgG) cryoglobulinaemia. Clin Exp Immunol. 1966 Jul;1(3):337–339. [PMC free article] [PubMed] [Google Scholar]
  17. Smith B. D. Sarcoidosis with recurrent thrombophlebitis and idiopathic steatorrhoea. Proc R Soc Med. 1966 Jun;59(6):569–570. [PMC free article] [PubMed] [Google Scholar]
  18. Soltoft J. Immunoglobulin-containing cells in non-tropical sprue. Clin Exp Immunol. 1970 Mar;6(3):413–420. [PMC free article] [PubMed] [Google Scholar]
  19. TAYLOR K. B., TRUELOVE S. C., THOMSON D. L., WRIGHT R. An immunological study of coeliac disease and idiopathic steatorrhoea. Serological reactions to gluten and milk proteins. Br Med J. 1961 Dec 30;2(5269):1727–1731. doi: 10.1136/bmj.2.5269.1727. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Turkington R. W., Buckley C. E., 3rd Macrocryoglobulinemia and sarcoidosis. Am J Med. 1966 Jan;40(1):156–164. doi: 10.1016/0002-9343(66)90197-5. [DOI] [PubMed] [Google Scholar]
  21. Wager O., Räsänen J. A., Lassus A., Mustakallio K. K. Mixed cryoimmunoglobulins. Acta Pathol Microbiol Scand. 1967;69(4):610–611. doi: 10.1111/j.1699-0463.1967.tb03769.x. [DOI] [PubMed] [Google Scholar]
  22. Weinstein W. M., Saunders D. R., Tytgat G. N., Rubin C. E. Collagenous sprue--an unrecognized type of malabsorption. N Engl J Med. 1970 Dec 10;283(24):1297–1301. doi: 10.1056/NEJM197012102832401. [DOI] [PubMed] [Google Scholar]
  23. Zinneman H. H., Levi D., Seal U. S. On the nature of cryoglobulins. J Immunol. 1968 Mar;100(3):594–603. [PubMed] [Google Scholar]

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