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. 1972 May;13(5):361–365. doi: 10.1136/gut.13.5.361

Inhibition of pancreatic secretion in man by cigarette smoking

T E Bynum, Travis E Solomon, Leonard R Johnson, Eugene D Jacobson
PMCID: PMC1412225  PMID: 5036091

Abstract

Cigarette smoking has been linked to an elevated incidence of duodenal ulcer disease in smokers, although the mechanism is unclear. In 23 young normal subjects single or double secretin tests were performed during non-smoking and smoking periods. Cigarette smoking inhibited the secretion of pancreatic juice and bicarbonate in light smokers (< one pack/day for < three years). Heavy smokers (> one pack/day for > three years) exhibited depressed pancreatic secretory rates during non-smoking periods. Inhibition of pancreatic alkaline secretion by cigarette smoking could be the link between the habit and duodenal ulcer disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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