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. 1979 Jul;20(7):559–564. doi: 10.1136/gut.20.7.559

Intestinal absorption of cholecalciferol in alcoholic liver disease and primary biliary cirrhosis.

J M Barragry, R G Long, M W France, M R Wills, B J Boucher, S Sherlock
PMCID: PMC1412508  PMID: 226459

Abstract

The intestinal absorption of (3H)cholecalciferol was studied in five patients with alcoholic liver disease, six patients with primary biliary cirrhosis, and 15 healthy subjects. The rate of appearance in plasma of (3H)cholecalciferol after oral ingestion and the subsequent appearance of (3H) polar metabolites in the alcoholic subjects were similar to those in the healthy subjects. In subjects with primary biliary cirrhosis the rate of appearance in plasma of (3H)cholecalciferol was significantly reduced. The rate of appearance of labelled polar metabolites of cholecalciferol was also lower in this group, suggesting that increased removal of labelled vitamin by conversion into more polar metabolites could not account for the reduced plasma (3H)cholecalciferol response. It is suggested that intestinal absorption of cholecalciferol is usually normal in alcoholic liver disease but impaired in primary biliary cirrhosis. Hepatic 25-hydroxylation is normal in alcoholic liver disease but may be defective in primary biliary cirrhosis.

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Selected References

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  1. ATKINSON M., NORDIN B. E., SHERLOCK S. Malabsorption and bone disease in prolonged obstructive jaundice. Q J Med. 1956 Jul;25(99):299–312. [PubMed] [Google Scholar]
  2. Barragry J. M., France M. W., Corless D., Gupta S. P., Switala S., Boucher B. J., Cohen R. D. Intestinal cholecalciferol absorption in the elderly and in younger adults. Clin Sci Mol Med. 1978 Aug;55(2):213–220. doi: 10.1042/cs0550213. [DOI] [PubMed] [Google Scholar]
  3. Compston J. E., Thompson R. P. Intestinal absorption of 25-hydroxyvitamin D and osteomalacia in primary biliary cirrhosis. Lancet. 1977 Apr 2;1(8014):721–724. doi: 10.1016/s0140-6736(77)92167-5. [DOI] [PubMed] [Google Scholar]
  4. Edelstein S., Charman M., Lawson D. E., Kodicek E. Competitive protein-binding assay for 25-hydroxycholecalciferol. Clin Sci Mol Med. 1974 Feb;46(2):231–240. doi: 10.1042/cs0460231. [DOI] [PubMed] [Google Scholar]
  5. Eggstein M., Kreutz F. H. Eine neue Bestimmung der Neutralfette im Blutserum und Gewebe. I. Prinzip, Durchführung und Besprechung der Methode. Klin Wochenschr. 1966 Mar 1;44(5):262–267. doi: 10.1007/BF01747716. [DOI] [PubMed] [Google Scholar]
  6. FOLCH J., LEES M., SLOANE STANLEY G. H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957 May;226(1):497–509. [PubMed] [Google Scholar]
  7. Fraser D. R., Kodicek E. Unique biosynthesis by kidney of a biological active vitamin D metabolite. Nature. 1970 Nov 21;228(5273):764–766. doi: 10.1038/228764a0. [DOI] [PubMed] [Google Scholar]
  8. Haddad J. G., Chyu K. J. Competitive protein-binding radioassay for 25-hydroxycholecalciferol. J Clin Endocrinol Metab. 1971 Dec;33(6):992–995. doi: 10.1210/jcem-33-6-992. [DOI] [PubMed] [Google Scholar]
  9. Heaton K. W., Lever J. V., Barnard D. Osteomalacia associated with cholestyramine therapy for postileectomy diarrhea. Gastroenterology. 1972 Apr;62(4):642–646. [PubMed] [Google Scholar]
  10. Hepner G. W., Roginsky M., Moo H. F. Abnormal vitamin D metabolism in patients with cirrhosis. Am J Dig Dis. 1976 Jul;21(7):527–532. doi: 10.1007/BF01464758. [DOI] [PubMed] [Google Scholar]
  11. Jung R. T., Davie M., Hunter J. O., Chalmers T. M., Lawson D. E. Abnormal vitamin D metabolism in cirrhosis. Gut. 1978 Apr;19(4):290–293. doi: 10.1136/gut.19.4.290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kehayoglou A. K., Holdsworth C. D., Agnew J. E., Whelton M. J., Sherlock S. Bone disease and calcium absorption in primary biliary cirrhosis with special reference to vitamin-D therapy. Lancet. 1968 Apr 6;1(7545):715–718. doi: 10.1016/s0140-6736(68)92164-8. [DOI] [PubMed] [Google Scholar]
  13. Krawitt E. L., Grundman M. J., Mawer E. B. Absorption, hydroxylation, and excretion of vitamin D3 in primary biliary cirrhosis. Lancet. 1977 Dec 17;2(8051):1246–1249. doi: 10.1016/s0140-6736(77)92660-5. [DOI] [PubMed] [Google Scholar]
  14. Long R. G., Meinhard E., Skinner R. K., Varghese Z., Wills M. R., Sherlock S. Clinical, biochemical, and histological studies of osteomalacia, osteoporosis, and parathyroid function in chronic liver disease. Gut. 1978 Feb;19(2):85–90. doi: 10.1136/gut.19.2.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Long R. G., Skinner R. K., Wills M. R., Sherlock S. Serum-25-hydroxy-vitamin-D in untreated parenchymal and cholestatic liver disease. Lancet. 1976 Sep 25;2(7987):650–652. doi: 10.1016/s0140-6736(76)92463-6. [DOI] [PubMed] [Google Scholar]
  16. Long R. G., Wills M. R. Hepatic osteodystrophy. Br J Hosp Med. 1978 Sep;20(3):312–321. [PubMed] [Google Scholar]
  17. Mawer E. B., Schaefer K., Lumb G. A., Stanbury S. W. The metabolism of isotopically labelled vitamin D3 in man: the influence of the state of vitamin D nutrition. Clin Sci. 1971 Jan;40(1):39–53. doi: 10.1042/cs0400039. [DOI] [PubMed] [Google Scholar]
  18. Ponchon G., DeLuca H. F. Ethanol-induced artifacts in the metabolism of 3H-vitamin D3. Proc Soc Exp Biol Med. 1969 Jul;131(3):727–731. doi: 10.3181/00379727-131-33962. [DOI] [PubMed] [Google Scholar]
  19. Ponchon G., Kennan A. L., DeLuca H. F. "Activation" of vitamin D by the liver. J Clin Invest. 1969 Nov;48(11):2032–2037. doi: 10.1172/JCI106168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Scheuer P. Primary biliary cirrhosis. Proc R Soc Med. 1967 Dec;60(12):1257–1260. [PMC free article] [PubMed] [Google Scholar]
  21. Skinner R. K., Sherlock S., Long R. G., Wilis M. R. 25-Hydroxylation of vitamin D in primary biliary cirrhosis. Lancet. 1977 Apr 2;1(8014):720–721. doi: 10.1016/s0140-6736(77)92166-3. [DOI] [PubMed] [Google Scholar]
  22. Stamp T. C. Intestinal absorption of 25-hydroxycholecalciferol. Lancet. 1974 Jul 20;2(7873):121–123. doi: 10.1016/s0140-6736(74)91553-0. [DOI] [PubMed] [Google Scholar]
  23. Thompson G. R., Lewis B., Booth C. C. Absorption of vitamin D3-3H in control subjects and patients with intestinal malabsorption. J Clin Invest. 1966 Jan;45(1):94–102. doi: 10.1172/JCI105327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Thompson W. G., Thompson G. R. Effect of cholestyramine on the absorption of vitamin D3 and calcium. Gut. 1969 Sep;10(9):717–722. doi: 10.1136/gut.10.9.717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Wagonfeld J. B., Nemchausky B. A., Bolt M., Horst J. V., Boyer J. L., Rosenberg I. H. Comparison of vitamin D and 25-hydroxy-vitamin-D in the therapy of primary biliary cirrhosis. Lancet. 1976 Aug 21;2(7982):391–394. doi: 10.1016/s0140-6736(76)92407-7. [DOI] [PubMed] [Google Scholar]
  26. Whelton M. J., Kehayoglou A. K., Agnew J. E., Turnberg L. A., Sherlock S. 47 Calcium abosrption in parenchymatous and biliary liver disease. Gut. 1971 Dec;12(12):978–983. doi: 10.1136/gut.12.12.978. [DOI] [PMC free article] [PubMed] [Google Scholar]

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