Abstract
A perfusion technique has been used to quantitate the effect of the amino acids glycine and alanine and the dipeptides glycyl-glycine and glycyl-L-alanine on sodium and water absorption from the human jejunum. Although no net absorption of sodium and water was seen in the absence of non-electrolytes, a significant stimulation occurred in the presence of both free amino acids and dipeptides. In the case of glycine and alanine, sodium and water absorption increased linearly with increasing concentration of the amino acid and saturation was not demonstrated over the range of concentrations studied. Molar ratios for net absorption of free amino acid and sodium were approximately 1:1 for all but the highest concentration of alanine. In contrast, the corresponding molar ratios for the two dipeptide solutions and sodium were approximately 1:2. Possible explanations for these observations are discussed.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adibi S. A. Intestinal transport of dipeptides in man: relative importance of hydrolysis and intact absorption. J Clin Invest. 1971 Nov;50(11):2266–2275. doi: 10.1172/JCI106724. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Adibi S. A. Leucine absorption rate and net movements of sodium and water in human jejunum. J Appl Physiol. 1970 Jun;28(6):753–757. doi: 10.1152/jappl.1970.28.6.753. [DOI] [PubMed] [Google Scholar]
- Christensen H. N., Liang M. Transport of diamino acids into the Ehrlich cell. J Biol Chem. 1966 Dec 10;241(23):5542–5551. [PubMed] [Google Scholar]
- Fleshler B., Butt J. H., Wismar J. D. Absorption of glycine and L-alanine by the human jejunum. J Clin Invest. 1966 Sep;45(9):1433–1441. doi: 10.1172/JCI105451. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fordtran J. S. Segmental perfusion techniques. Gastroenterology. 1969 May;56(5):987–989. [PubMed] [Google Scholar]
- Hellier M. D., Holdsworth C. D., McColl I., Perrett D. Dipeptide absorption in man. Gut. 1972 Dec;13(12):965–969. doi: 10.1136/gut.13.12.965. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hellier M. D., Holdsworth C. D., Perrett D., Thirumalai C. Intestinal depeptide transport in normal and cystinuric subjects. Clin Sci. 1972 Nov;43(5):659–668. doi: 10.1042/cs0430659. [DOI] [PubMed] [Google Scholar]
- Hellier M. D., Perrett D., Holdsworth C. D. Dipeptide absorption in cystinuria. Br Med J. 1970 Dec 26;4(5738):782–783. doi: 10.1136/bmj.4.5738.782. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Matthews D. M., Craft I. L., Geddes D. M., Wise I. J., Hyde C. W. Absorption of glycine and glycine peptides from the small intestine of the rat. Clin Sci. 1968 Dec;35(3):415–424. [PubMed] [Google Scholar]
- McMichael H. B., Webb J., Dawson A. M. The absorption of maltose and lactose in man. Clin Sci. 1967 Aug;33(1):135–145. [PubMed] [Google Scholar]
- Modigliani R., Bernier J. J. Absorption of glucose, sodium, and water by the human jejunum studied by intestinal perfusion with a proximal occluding balloon and at variable flow rates. Gut. 1971 Mar;12(3):184–193. doi: 10.1136/gut.12.3.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Munck B. G., Schultz S. G. Lysine transport across isolated rabbit ileum. J Gen Physiol. 1969 Feb;53(2):157–182. doi: 10.1085/jgp.53.2.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nalin D. R., Cash R. A., Islam R., Molla M., Phillips R. A. Oral maintenance therapy for cholera in adults. Lancet. 1968 Aug 17;2(7564):370–373. doi: 10.1016/s0140-6736(68)90591-6. [DOI] [PubMed] [Google Scholar]
- Nalin D. R., Cash R. A., Rahman M., Yunus M. Effect of glycine and glucose on sodium and water adsorption in patients with cholera. Gut. 1970 Sep;11(9):768–772. doi: 10.1136/gut.11.9.768. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHEDL H. P., CLIFTON J. A. SOLUTE AND WATER ABSORPTION BY THE HUMAN SMALL INTESTINE. Nature. 1963 Sep 28;199:1264–1267. doi: 10.1038/1991264a0. [DOI] [PubMed] [Google Scholar]
- Saltzman D. A., Rector F. C., Jr, Fordtran J. S. The role of intraluminal sodium in glucose absorption in vivo. J Clin Invest. 1972 Apr;51(4):876–885. doi: 10.1172/JCI106882. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schultz S. G., Curran P. F. Coupled transport of sodium and organic solutes. Physiol Rev. 1970 Oct;50(4):637–718. doi: 10.1152/physrev.1970.50.4.637. [DOI] [PubMed] [Google Scholar]
- Sladen G. E., Dawson A. M. Further studies on the perfusion method for measuring intestinal absorption in man: the effects of a proximal occlusive balloon and a mixing segment. Gut. 1970 Nov;11(11):947–954. doi: 10.1136/gut.11.11.947. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sladen G. E., Dawson A. M. Interrelationships between the absorptions of glucose, sodium and water by the normal human jejunum. Clin Sci. 1969 Feb;36(1):119–132. [PubMed] [Google Scholar]