Skip to main content
PMC home page
Gut logoLink to Gut
. 1973 Mar;14(3):196–203. doi: 10.1136/gut.14.3.196

Histopathological and electron microscopic studies of lymphangiectasia of the small intestine in Behçet's disease

Hitoshi Asakura, Akira Morita, Tetsuo Morishita, Masaharu Tsuchiya, Yoonosuke Watanabe, Yasuhiro Enomoto
PMCID: PMC1412626  PMID: 4700433

Abstract

The gastrointestinal involvement and immunological findings in 16 patients with Behçet's disease are described. Four of 15 biopsy specimens of jejunal mucosa showed marked lymphangiectasia in the lamina propria similar to the appearance which was thought to be a characteristic finding in protein-losing enteropathy. None of the patients had hypoproteinaemia. Increases in serum immunoglobulin IgA were proved in six of 15 cases; in IgM, five of 15; and in IgG, one of 15. Electron microscopic studies showed that there were thousands of precipitated lymph protein bodies in the extracellular spaces of the lamina propria. Ulcers and healed ulcers of the large intestine were studied by light microscopy.

Full text

PDF
199

Images in this article

198Fig. 1
on p.198
198Fig. 2
on p.198
199Fig. 3
on p.199
199Fig. 4
on p.199
200Fig. 7
on p.200
201Fig. 8
on p.201
201Fig. 9
on p.201

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASTALDI G., STROSSELLI E. Peroral biopsy of the intestinal mucosa in hepatic cirrhosis. Am J Dig Dis. 1960 Jul;5:603–612. doi: 10.1007/BF02290193. [DOI] [PubMed] [Google Scholar]
  2. BOE J., DALGAARD J. B., SCOTT D. Mucocutaneous-ocular syndrome with intestinal involvement; a clinical and pathological study of four fatal cases. Am J Med. 1958 Dec;25(6):857–867. doi: 10.1016/0002-9343(58)90058-5. [DOI] [PubMed] [Google Scholar]
  3. Cooper D., Penny R., Fiddes P. Autologous-plasma sensitisation in Behcet's disease. Lancet. 1971 May 1;1(7705):910–910. doi: 10.1016/s0140-6736(71)92468-8. [DOI] [PubMed] [Google Scholar]
  4. Dobbins W. O., 3rd Electron microscopic study of the intestinal mucosa in intestinal lymphangiectasia. Gastroenterology. 1966 Dec;51(6):1004–1017. [PubMed] [Google Scholar]
  5. Empey D. W. Rectal and colonic ulceration in Behçet's disease. Br J Surg. 1972 Mar;59(3):173–175. doi: 10.1002/bjs.1800590304. [DOI] [PubMed] [Google Scholar]
  6. Enoch B. A. Gangrene in Behcet's syndrome. Br Med J. 1969 Jul 5;3(5661):54–54. doi: 10.1136/bmj.3.5661.54-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Francis T. C. Recurrent aphthous stomatitis and Behcet's disease. A review. Oral Surg Oral Med Oral Pathol. 1970 Oct;30(4):476–486. doi: 10.1016/0030-4220(70)90161-1. [DOI] [PubMed] [Google Scholar]
  8. Haim S., Barzilai D., Hazani E. Involvement of veins in Behcet's syndrome. Br J Dermatol. 1971 Mar;84(3):238–241. doi: 10.1111/j.1365-2133.1971.tb14213.x. [DOI] [PubMed] [Google Scholar]
  9. Kalbian V. V., Challis M. T. Behçet's disease. Report of twelve cases with three manifesting as papilledema. Am J Med. 1970 Dec;49(6):823–829. doi: 10.1016/s0002-9343(70)80064-x. [DOI] [PubMed] [Google Scholar]
  10. Lehner T. Behçet's syndrome and autoimmunity. Br Med J. 1967 Feb 25;1(5538):465–467. doi: 10.1136/bmj.1.5538.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lehner T. Immunologic aspects of recurrent oral ulcers. Oral Surg Oral Med Oral Pathol. 1972 Jan;33(1):80–85. doi: 10.1016/0030-4220(72)90211-3. [DOI] [PubMed] [Google Scholar]
  12. MCDONAGH T. J., GUEFT B., PYUN K., ARIAS I. M. HYPOPROTEINEMIA, CHYLOUS ASCITES, STEATORRHEA, AND PROTEIN-LOSING ENTEROPATHY DUE TO CHRONIC INFLAMMATORY OBSTRUCTION OF MAJOR INTESTINAL LYMPH VESSELS. Gastroenterology. 1965 May;48:642–647. [PubMed] [Google Scholar]
  13. MISTILIS S. P., SKYRING A. P., STEPHEN D. D. INTESTINAL LYMPHANGIECTASIA MECHANISM OF ENTERIC LOSS OF PLASMA-PROTEIN AND FAT. Lancet. 1965 Jan 9;1(7376):77–79. doi: 10.1016/s0140-6736(65)91657-0. [DOI] [PubMed] [Google Scholar]
  14. Majima Y. Interchangeability of fatty acids between phospholipids and esterified cholesterol in the plasma. Keio J Med. 1972 Mar;21(1):1–11. doi: 10.2302/kjm.21.1. [DOI] [PubMed] [Google Scholar]
  15. Mason R. M., Barnes C. G. Behçet's syndrome with arthritis. Ann Rheum Dis. 1969 Mar;28(2):95–103. doi: 10.1136/ard.28.2.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Mowat A. G., Hothersall T. E. Gangrene in Behçet's syndrome. Br Med J. 1969 Jun 7;2(5657):636–636. doi: 10.1136/bmj.2.5657.636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. O'Duffy J. D., Carney J. A., Deodhar S. Behçet's disease. Report of 10 cases, 3 with new manifestations. Ann Intern Med. 1971 Oct;75(4):561–570. doi: 10.7326/0003-4819-75-4-561. [DOI] [PubMed] [Google Scholar]
  18. Oshima Y., Shimizu T., Yokohari R., Matsumoto T., Kano K., Kagami T., Nagaya H. Clinical Studies on Behçet's Syndrome. Ann Rheum Dis. 1963 Jan;22(1):36–45. doi: 10.1136/ard.22.1.36. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. POMERANTZ M., WALDMANN T. A. SYSTEMIC LYMPHATIC ABNORMALITIES ASSOCIATED WITH GASTROINTESTINAL PROTEIN LOSS SECONDARY TO INTESTINAL LYMPHANGIECTASIA. Gastroenterology. 1963 Dec;45:703–711. [PubMed] [Google Scholar]
  20. Ramsay C. A. Behçet's syndrome with large bowel involvement. Proc R Soc Med. 1967 Feb;60(2):185–187. [PMC free article] [PubMed] [Google Scholar]
  21. Shimizu T., Katsuta Y., Oshima Y. Immunological studies on Behçet's syndrome. Ann Rheum Dis. 1965 Sep;24(5):494–500. doi: 10.1136/ard.24.5.494. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Strober W., Wochner R. D., Carbone P. P., Waldmann T. A. Intestinal lymphangiectasia: a protein-losing enteropathy with hypogammaglobulinemia, lymphocytopenia and impaired homograft rejection. J Clin Invest. 1967 Oct;46(10):1643–1656. doi: 10.1172/JCI105656. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. WALDMANN T. A., STEINFELD J. L., DUTCHER T. F., DAVIDSON J. D., GORDON R. S., Jr The role of the gastrointestinal system in "idiopathic hypoproteinemia". Gastroenterology. 1961 Sep;41:197–207. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES