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. 1973 Nov;14(11):870–874. doi: 10.1136/gut.14.11.870

Secretin cells in coeliac disease

Julia M Polak, A G E Pearse, Susan Van Noorden, S R Bloom, Mary A Rossiter
PMCID: PMC1412853  PMID: 4586733

Abstract

Immunofluorescence (anti-secretin), cytochemical, and ultrastructural studies were carried out on jejunal biopsies from 16 children with coeliac disease and from 17 controls with suspected malabsorption but normal jejunal morphology.

In 11 of the 16 coeliacs there was generalized hyperplasia of endocrine cells and, specifically, of the secretin (S) cells.

Further studies, on adult coeliacs as well as on children, combined with serum secretin assays, may establish whether the S cells are abnormally storing hormone because of inability to release it or because of excess production.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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