Abstract
Two consecutive trials of out-patient treatment for mild cases of active ulcerative colitis are described. In the first trial oral prednisone gave significantly better results than a placebo. In the second trial “salazopyrin” gave final results approaching those of prednisone, although over a longer time and with a higher incidence of unpleasant side-effects, but topical hydrocortisone gave disappointing results, probably because the technique of administration was not suitable for ordinary out-patient use.
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Selected References
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- MOERTEL C. G., BARGEN J. A. A critical analysis of the use of salicylazosulfapyridine in chronic ulcerative colitis. Ann Intern Med. 1959 Nov;51:879–889. doi: 10.7326/0003-4819-51-5-879. [DOI] [PubMed] [Google Scholar]
- NABARRO J. D., MOXHAM A., WALKER G., SLATER J. D. Rectal hydrocortisone. Br Med J. 1957 Aug 3;2(5039):272–274. doi: 10.1136/bmj.2.5039.272. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Newell A. C., Jones F. A. Observations on the Management of Idiopathic Proctitis [Abridged]. Proc R Soc Med. 1958 Jun;51(6):431–431. [PMC free article] [PubMed] [Google Scholar]
- SVARTZ N. The treatment of ulcerative colitis. Gastroenterologia. 1956;86(5):683–688. doi: 10.1159/000200641. [DOI] [PubMed] [Google Scholar]
- TRUELOVE S. C. Treatment of ulcerative colitis with local hydrocortisone. Proc R Soc Med. 1958 Jun;51(6):429–431. [PMC free article] [PubMed] [Google Scholar]
- WATKINSON G. Treatment of ulcerative colitis with topical hydrocortisone hemisuccinate sodium; a controlled trial employing restricted sequential analysis. Br Med J. 1958 Nov 1;2(5104):1077–1082. doi: 10.1136/bmj.2.5104.1077. [DOI] [PMC free article] [PubMed] [Google Scholar]