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. 1961 Sep;2(3):218–224. doi: 10.1136/gut.2.3.218

Co58B12 absorption (hepatic surface count) after gastrectomy, ileal resection, and in coeliac disorders

D J Fone, W T Cooke, M J Meynell, E L Harris
PMCID: PMC1413278  PMID: 13893896

Abstract

This paper demonstrates that the hepatic surface counting technique is a reliable and satisfactory method of estimating the absorption of radioactive vitamin B12. It does not require the collection of faeces or urine and is therefore particularly useful in studying out-patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BADENOCH J., EVANS J. R., RICHARDS W. C., WITTS L. J. Megaloblastic anaemia following partial gastrectomy and gastro-enterostomy. Br J Haematol. 1955 Oct;1(4):339–344. doi: 10.1111/j.1365-2141.1955.tb05518.x. [DOI] [PubMed] [Google Scholar]
  2. BAIRD I. M., WILSON G. M. The pathogenesis of anaemia after partial gastrectomy. II. Iron absorption after partial gastrectomy. Q J Med. 1959 Jan;28(109):35–41. [PubMed] [Google Scholar]
  3. BAKER S. J., MOLLIN D. L. The relationship between intrinsic factor and the intestinal absorption of vitamin B12. Br J Haematol. 1955 Jan;1(1):46–51. [PubMed] [Google Scholar]
  4. BOOTH C. C., MOLLIN D. L. The site of absorption of vitamin B12 in man. Lancet. 1959 Jan 3;1(7062):18–21. doi: 10.1016/s0140-6736(59)90979-1. [DOI] [PubMed] [Google Scholar]
  5. COOKE W. T. Adult coeliac disease and other disorders associated with steatorrhoea. Br Med J. 1958 Aug 2;2(5091):261–265. doi: 10.1136/bmj.2.5091.261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. COOKE W. T., FOWLER D. I., COX E. V., GADDIE R., MEYNELL M. J. The clinical significance of seromucoids in regional ileitis and ulcerative colitis. Gastroenterology. 1958 May;34(5):910–919. [PubMed] [Google Scholar]
  7. COOKE W. T., PEENEY A. L. P., HAWKINS C. F. Symptoms, signs and diagnostic features of idiopathic steatorrhoea. Q J Med. 1953 Jan;22(85):59–78. [PubMed] [Google Scholar]
  8. COX E. V., MEYNELL M. J., GADDIE R., COOKE W. T. Interrelation of vitamin B12 and iron. Lancet. 1959 Dec 5;2(7110):998–1001. doi: 10.1016/s0140-6736(59)91468-0. [DOI] [PubMed] [Google Scholar]
  9. DOIG A., GIRDWOOD R. H. The absorption of folic acid and labelled cyanocobalamin in intestinal malabsorption, with observations on the faecal excretion of fat and nitrogen and the absorption of glucose and xylose. Q J Med. 1960 Jul;29:333–374. [PubMed] [Google Scholar]
  10. FONE D. J., MEYNELL M. J., HARRIS E. L., COOKE W. T., BREWER D. B., COX E. V. Jejunal biopsy in adult coeliac disease and allied disorders. Lancet. 1960 Apr 30;1(7131):933–939. doi: 10.1016/s0140-6736(60)90832-1. [DOI] [PubMed] [Google Scholar]
  11. GLASS G. B. J., BOYD L. J., GELLIN G. A., STEPHANSON L. Uptake of radioactive vitamin B12 by the liver in humans: test for measurement of intestinal absorption of vitamin B12 and intrinsic factor activity. Arch Biochem Biophys. 1954 Jul;51(1):251–257. doi: 10.1016/0003-9861(54)90472-5. [DOI] [PubMed] [Google Scholar]
  12. GLASS G. B. J. Deposition and storage of vitamin B12 in the normal and diseased liver. Gastroenterology. 1959 Feb;36(2):180–192. [PubMed] [Google Scholar]
  13. GLASS G. B., SPEER F. D., NIEBURGS H. E., ISHIMORI A., JONES E. L., BAKER H., SCHWARTZ S. A., SMITH R. Gastric atrophy, atrophic gastritis, and gastric secretory failure. Correlative study by suction biopsy and exfoliative cytology of gastric mucosa, paper electrophoretic and secretory assays of gastric secretion, and measurements of intestinal absorption and blood levels of vitamin B12. Gastroenterology. 1960 Oct;39:429–453. [PubMed] [Google Scholar]
  14. HEINLE R. W., WELCH A. D., SCHARF V., MEACHAM G. C., PRUSOFF W. H. Studies of excretion (and absorption) of Co60 labeled vitamin B12 in pernicious anemia. Trans Assoc Am Physicians. 1952;65:214–222. [PubMed] [Google Scholar]
  15. LOEWENSTEIN F. Absorption of cobalt60-labeled vitamin B12 after subtotal gastrectomy. Blood. 1958 Apr;13(4):339–347. [PubMed] [Google Scholar]
  16. MACLEAN L. D. Incidence of megaloblastic anemia after subtotal gastrectomy. N Engl J Med. 1957 Aug 8;257(6):262–265. doi: 10.1056/NEJM195708082570603. [DOI] [PubMed] [Google Scholar]
  17. MEYNELL M. J., COOKE W. T., COX E. V., GADDIE R. Serum-cyanocobalamin level in chronic intestinal disorders. Lancet. 1957 May 4;272(6975):901–904. doi: 10.1016/s0140-6736(57)91223-0. [DOI] [PubMed] [Google Scholar]
  18. MOLLIN D. L., BOOTH C. C., BAKER S. J. The absorption of vitamin B12 in control subjects, in Addisonian pernicious anaemia and in the malabsorption syndrome. Br J Haematol. 1957 Oct;3(4):412–428. doi: 10.1111/j.1365-2141.1957.tb05540.x. [DOI] [PubMed] [Google Scholar]
  19. OXENHORN S., ESTREN S., WASSERMAN L. R., ADLERSBERG D. Malabsorption syndrome: intestinal absorption of vitamin B12. Ann Intern Med. 1958 Jan;48(1):30–38. doi: 10.7326/0003-4819-48-1-30. [DOI] [PubMed] [Google Scholar]
  20. SCHILLING R. F. Intrinsic factor studies II. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12. J Lab Clin Med. 1953 Dec;42(6):860–866. [PubMed] [Google Scholar]
  21. WILLIAMS A. W., COGHILL N. F., EDWARDS F. The gastric mucosa in pernicious anaemia: biopsy studies. Br J Haematol. 1958 Oct;4(4):457–464. doi: 10.1111/j.1365-2141.1958.tb06047.x. [DOI] [PubMed] [Google Scholar]

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