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. 1963 Sep;4(3):231–235. doi: 10.1136/gut.4.3.231

The vitamin B12 content of human liver tissue obtained by aspiration biopsy

R A Joske
PMCID: PMC1413443  PMID: 14058264

Abstract

It is possible to estimate the vitamin B12 content of liver specimens obtained by needle biopsy. The liver B12 content is not related to the serum levels of vitamin B12, bilirubin, alkaline phosphatase, glutamic-oxaloacetic transaminase, or albumin. It is reduced in a number of pathological conditions of the liver and the reasons for this are discussed, as also are the factors determining the content of B12 in the normal liver.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEARD M. F., PITNEY W. R., SANNEMAN E. H. Serum concentrations of vitamin B12 in patients suffering from leukemia. Blood. 1954 Aug;9(8):789–794. [PubMed] [Google Scholar]
  2. COWLING D. C., MACKAY I. R. Serum vitamin B12 levels in liver disease. Med J Aust. 1959 Oct 17;46(2):558–562. doi: 10.5694/j.1326-5377.1959.tb129295.x. [DOI] [PubMed] [Google Scholar]
  3. DROUET P. L., WOLFF, KARLIN, RAUBER G. Etude de la vitamine B12 hépatique par la ponction-biopsie premiers résultats dans la maladie de Biermer. 1951 Feb 23-Mar 2Bull Mem Soc Med Hop Paris. 67(7-8):281–286. [PubMed] [Google Scholar]
  4. DUNN M., MARTINS J., REISSMANN K. R. The disappearance rate of glutamic oxalacetic transaminase from the circulation and its distribution in the body's fluid compartments and secretions. J Lab Clin Med. 1958 Feb;51(2):259–265. [PubMed] [Google Scholar]
  5. GIRDWOOD R. H. The occurrence of growth factors for Lactobacillus leichmannii; Streptococcus faecalis and Leuconostoc citrovorum in the tissues of pernicious anaemia patients and controls. Biochem J. 1952 Sep;52(1):58–63. doi: 10.1042/bj0520058. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GLASS G. B. J. Deposition and storage of vitamin B12 in the normal and diseased liver. Gastroenterology. 1959 Feb;36(2):180–192. [PubMed] [Google Scholar]
  7. GROSSOWICZ N., HOCHMAN A., ARONOVITCH J., IZAK G., RACHMILEWITZ M. Malignant growth in the liver and serum-vitamin-B12 levels. Lancet. 1957 Jun 1;272(6979):1116–1117. doi: 10.1016/s0140-6736(57)91682-3. [DOI] [PubMed] [Google Scholar]
  8. HALSTED J. A., HVOLBOLL E., SCHICK G., SWENDSEID M. E. The vitamin B12 content of human liver tissue and its nutritional significance; a comparison study of various age groups. Blood. 1957 Jan;12(1):24–28. [PubMed] [Google Scholar]
  9. MACKAY I. R., COWLING D. C., GRAY A. Highly raised serum vitamin B12 levels in obstructive hepatic necrosis. Br Med J. 1957 Oct 5;2(5048):800–801. doi: 10.1136/bmj.2.5048.800. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. NELSON R. S., DOCTOR V. M. The vitamin B12 content of human liver as determined by bio-assay of needle biopsy material. Ann Intern Med. 1958 Dec;49(6):1361–1367. doi: 10.7326/0003-4819-49-6-1361. [DOI] [PubMed] [Google Scholar]
  11. NICHOLAS D. R., PITNEY W. R. Microbiological assay of vitamin B12 content of serum using Euglena gracilis. Aust J Exp Biol Med Sci. 1958 Dec;36(6):603–608. doi: 10.1038/icb.1958.65. [DOI] [PubMed] [Google Scholar]
  12. PITNEY W. R., BEARD M. F., VAN LOON E. J. Observations on the bound form of vitamin B12 in human serum. J Biol Chem. 1954 Mar;207(1):143–152. [PubMed] [Google Scholar]
  13. ROSS G. I. M. Vitamin B12 assay in body fluids using Euglena gracilis. J Clin Pathol. 1952 Aug;5(3):250–256. doi: 10.1136/jcp.5.3.250. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. STOKES J. B., FORTUNE C. Megaloblastic anaemia associated with anticonvulsant drug therapy. Australas Ann Med. 1958 May;7(2):118–125. doi: 10.1111/imj.1958.7.2.118. [DOI] [PubMed] [Google Scholar]

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