Abstract
A case of pulmonary infection with Mycobacterium tuberculosis in a patient with the acquired immune deficiency syndrome (AIDS) was studied. Diagnosis of AIDS was confirmed by the finding of pulmonary M tuberculosis with oral and oesophageal candidiasis accompanied by characteristic immunological changes with evidence of infection with human T cell lymphotropic virus III. Treatment of this patient was complicated by an unusual drug interaction between rifampicin and ketoconazole, leading to subtherapeutic serum concentrations and poor clinical response to treatment. Intravenous treatment was more effective than oral treatment. This drug interaction should be studied in greater detail as ketoconazole and rifampicin may be used together to treat patients with candidiasis and infection with M tuberculosis.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Engelhard D., Stutman H. R., Marks M. I. Interaction of ketoconazole with rifampin and isoniazid. N Engl J Med. 1984 Dec 27;311(26):1681–1683. doi: 10.1056/NEJM198412273112606. [DOI] [PubMed] [Google Scholar]
- Pape J. W., Liautaud B., Thomas F., Mathurin J. R., St Amand M. M., Boncy M., Pean V., Pamphile M., Laroche A. C., Johnson W. D., Jr Characteristics of the acquired immunodeficiency syndrome (AIDS) in Haiti. N Engl J Med. 1983 Oct 20;309(16):945–950. doi: 10.1056/NEJM198310203091603. [DOI] [PubMed] [Google Scholar]
- Pitchenik A. E., Fischl M. A., Dickinson G. M., Becker D. M., Fournier A. M., O'Connell M. T., Colton R. M., Spira T. J. Opportunistic infections and Kaposi's sarcoma among Haitians: evidence of a new acquired immunodeficiency state. Ann Intern Med. 1983 Mar;98(3):277–284. doi: 10.7326/0003-4819-98-3-277. [DOI] [PubMed] [Google Scholar]
- Pitchenik A. E., Rubinson H. A. The radiographic appearance of tuberculosis in patients with the acquired immune deficiency syndrome (AIDS) and pre-AIDS. Am Rev Respir Dis. 1985 Mar;131(3):393–396. doi: 10.1164/arrd.1985.131.3.393. [DOI] [PubMed] [Google Scholar]
- Vieira J., Frank E., Spira T. J., Landesman S. H. Acquired immune deficiency in Haitians: opportunistic infections in previously healthy Haitian immigrants. N Engl J Med. 1983 Jan 20;308(3):125–129. doi: 10.1056/NEJM198301203080303. [DOI] [PubMed] [Google Scholar]