Skip to main content
PMC home page
Gut logoLink to Gut
. 1979 Jan;20(1):68–74. doi: 10.1136/gut.20.1.68

Comparison of two doses of cimetidine and placebo in the treatment of duodenal ulcer: a multicentre trial.

PMCID: PMC1418957  PMID: 367885

Abstract

Endoscopy, clinical assessment, and laboratory studies were used to compare, in a double-blind multicentre trial, the effects on patients with duodenal ulceration of treatment for four weeks by either placebo or 1 g/day cimetidine, or 2 g/day cimetidine. Ulcer healing occurred in 28% of patients on placebo, 61% of patients on 1 g cimetidine daily, and 70% of patients on 2 g cimetidine daily. Thus cimetidine conferred an advantage over placebo, but the effects of the two doses of cimetidine were not shown to be different. Symptomatic improvement in patients given cimetidine was usually marked and occurred early. Patients were required to report all symptoms, but the only symptom which might have been caused by cimetidine was headache in 5% of patients. Biochemical studies showed significant (though slight) rises in serum uric acid, and serum creatinine but no significant changes occurred in the serum levels of liver enzymes. This study confirms that 1 g is a suitable daily dose of cimetidine for the treatment of duodenal ulceration.

Full text

PDF
74

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bank S., Barbezat G. O., Novis B. H., Tim L. O., Odes H. S., Helman C., Narunsky L., Duys P. J., Marks I. N. Histamine H2-receptor antagonists in the treatment of duodenal ulcers. S Afr Med J. 1976 Oct 16;50(44):1781–1785. [PubMed] [Google Scholar]
  2. Blackwood W. S., Maudgal D. P., Pickard R. G., Lawrence D., Northfield T. C. Cimetidine in duodenal ulcer. Controlled trial. Lancet. 1976 Jul 24;2(7978):174–176. doi: 10.1016/s0140-6736(76)92347-3. [DOI] [PubMed] [Google Scholar]
  3. Bodemar G., Walan A. Cimetidine in the treatment of active duodenal and prepyloric ulcers. Lancet. 1976 Jul 24;2(7978):161–164. doi: 10.1016/s0140-6736(76)92342-4. [DOI] [PubMed] [Google Scholar]
  4. Bodemar G., Walan A. Maintenance treatment of recurrent peptic ulcer by cimetidine. Lancet. 1978 Feb 25;1(8061):403–407. doi: 10.1016/s0140-6736(78)91200-x. [DOI] [PubMed] [Google Scholar]
  5. Gray G. R., Smith I. S., McKenzie I., Crean G. P., Gillespie G. Oral cimetidine in severe duodenal ulceration. A double-blind controlled trial. Lancet. 1977 Jan 1;1(8001):4–7. doi: 10.1016/s0140-6736(77)91650-6. [DOI] [PubMed] [Google Scholar]
  6. Gudmand-Høyer E., Jensen K. B., Krag E., Rask-Madsen J., Rahbek I., Rune S. J., Wulff H. R. Prophylactic effect of cimetidine in duodenal ulcer disease. Br Med J. 1978 Apr 29;1(6120):1095–1097. doi: 10.1136/bmj.1.6120.1095. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Haggie S. J., Fermont D. C., Wyllie J. H. Treatment of duodenal ulcer with cimetidine. Lancet. 1976 May 8;1(7967):983–984. doi: 10.1016/s0140-6736(76)91859-6. [DOI] [PubMed] [Google Scholar]
  8. Hetzel D. J., Taggart G. J., Hansky J., Hecker R., Shearman D. J. Cimetidine in the treatment of duodenal ulcer. Med J Aust. 1977 Mar 5;1(10):317–319. [PubMed] [Google Scholar]
  9. Moshal M. G., Spitaels J. M., Bhoola R. Treatment of duodenal ulcers with cimetidine. S Afr Med J. 1977 Oct 29;52(19):760–763. [PubMed] [Google Scholar]
  10. Pounder R. E., Williams J. G., Milton-Thompson G. J., Misiewicz J. J. 24-hour control of intragastric acidity by cimetidine in duodenal-ulcer patients. Lancet. 1975 Nov 29;2(7944):1069–1072. doi: 10.1016/s0140-6736(75)90434-1. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES