Abstract
A histological study of peroral jejunal biopsies and resection specimens from patients with malignant histiocytosis of the intestine (MHI) has revealed characteristic lesions consisting of intramucosal histiocytic aggregations which invade surface and crypt epithelium. These lesions are found in 'uninvolved' jejunal mucosa in the presence of obvious tumour elsewhere and also in peroral jejunal biopsies many years earlier than the diagnosis of MHI. It is suggested that they represent the early lesion and their recognition in peroral jejunal biopsies could be important in improving the prognosis of the disease.
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- Austad W. I., Cornes J. S., Gough K. R., McCarthy C. F., Read A. E. Steatorrhea and malignant lymphoma. The relationship of malignant tumors of lymphoid tissue and celiac disease. Am J Dig Dis. 1967 May;12(5):475–490. doi: 10.1007/BF02233180. [DOI] [PubMed] [Google Scholar]
- Hodges J. R., Isaacson P., Smith C. L., Sworn M. J. Malignant histiocytosis of the intestine. Dig Dis Sci. 1979 Aug;24(8):631–638. doi: 10.1007/BF01333708. [DOI] [PubMed] [Google Scholar]
- Holmes G. K., Stokes P. L., Sorahan T. M., Prior P., Waterhouse J. A., Cooke W. T. Coeliac disease, gluten-free diet, and malignancy. Gut. 1976 Aug;17(8):612–619. doi: 10.1136/gut.17.8.612. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hourihane D. O., Weir D. G. Malignant celiac syndrome. Report of two cases with malabsorption and microscopic foci of intestinal lymphoma. Gastroenterology. 1970 Jul;59(1):130–139. [PubMed] [Google Scholar]
- Isaacson P., Wright D. H. Intestinal lymphoma associated with malabsorption. Lancet. 1978 Jan 14;1(8055):67–70. doi: 10.1016/s0140-6736(78)90004-1. [DOI] [PubMed] [Google Scholar]
- Isaacson P., Wright D. H. Malignant histiocytosis of the intestine. Its relationship to malabsorption and ulcerative jejunitis. Hum Pathol. 1978 Nov;9(6):661–677. doi: 10.1016/s0046-8177(78)80049-5. [DOI] [PubMed] [Google Scholar]
- Mepham B. L., Frater W., Mitchell B. S. The use of proteolytic enzymes to improve immunoglobulin staining by the PAP technique. Histochem J. 1979 May;11(3):345–357. doi: 10.1007/BF01005033. [DOI] [PubMed] [Google Scholar]
- Morson B. C., Pang L. S. Rectal biopsy as an aid to cancer control in ulcerative colitis. Gut. 1967 Oct;8(5):423–434. doi: 10.1136/gut.8.5.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Perera D. R., Weinstein W. M., Rubin C. E. Symposium on pathology of the gastrointestinal tract-Part II. Small intestinal biopsy. Hum Pathol. 1975 Mar;6(2):157–217. doi: 10.1016/s0046-8177(75)80176-6. [DOI] [PubMed] [Google Scholar]