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. 1980 Feb;21(2):123–127. doi: 10.1136/gut.21.2.123

Plasma clearance of oral and intravenous cholic acid in subjects with and without chronic liver disease.

I T Gilmore, R P Thompson
PMCID: PMC1419343  PMID: 7380333

Abstract

The apparent plasms clearances of tracer amounts of radiolabelled cholic acid given orally or intravenously were compared in 14 control subjects and 20 patients with chronic liver disease. The clearance after oral administration was the more sensitive in detecting chronic liver disease and correlated better with the fasting levels of endogenous serum bile acid. This agrees with the predicted effects on clearance of hepatocellular damage and portal-systemic shunting of blood after the two routes of administration. The estimated hepatic extraction ratio, calculated from the ratio of the oral and intravenous clearances, was 0.77+/-0.02 (mean+/-SEM) in control subjects, 0.64+/-0.03 in patients with anicteric chronic liver disease, and 0.46+/-0.05 in those with icteric chronic liver disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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