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. 1980 Oct;21(10):843–847. doi: 10.1136/gut.21.10.843

Effect of bile acid perfusion on colonic motor function in patients with the irritable colon syndrome.

I Taylor, P Basu, P Hammond, C Darby, M Flynn
PMCID: PMC1419391  PMID: 7439803

Abstract

A study was performed to determine the effect of bile acid perfusion on motility in the sigmoid colon of patients with the irritable colon syndrome compared with normal subjects. Deoxycholic acid (15 mM) statistically significantly increased motility in normal subjects (control 25.0 +/- 6.4%, perfusion 71.4 +/- 7.2%, P < 0.05) but neither chenodeoxycholic acid nor cholic acid had any apparent effect. In patients with the irritable colon syndrome, however, deoxycholic acid at 5 mM concentration (control 29.8 +/- 4.2%, during perfusion 57.4 +/- 6.5%, P < 0.05) as well as at 15 mM concentration (control 19.4 +/- 5.7+, perfusion 57.8 +/- 9.6%, P < 0.05) statistically significantly increased rectosigmoid motility. Patients with the irritable colon syndrome had a high resting 0.033-0.066 Hz (2-4 c/m) electrical activity, whereas in normal subjects 0.1-0.15 Hz (6-9 c/m) activity was greater. However, there was no statistically significant alteration in either electrical rhythm during the period of bile acid perfusion. In conclusion, additional evidence is presented to suggest that deoxycholic acid is the only bile acid likely to be implicated in the motor disorder of the irritable colon syndrome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Billington D., Coleman R. Effects of bile salts of human erythrocytes. Plasma membrane vesiculation, phospholipid solubilization and their possible relationships to bile secretion. Biochim Biophys Acta. 1978 May 4;509(1):33–47. doi: 10.1016/0005-2736(78)90005-6. [DOI] [PubMed] [Google Scholar]
  2. CHAUDHARY N. A., TRUELOVE S. C. Human colonic motility: a comparative study of normal subjects, patients with ulcerative colitis, and patients with the irritable colon syndrome. III. Effects of emotions. Gastroenterology. 1961 Jan;40:27–36. [PubMed] [Google Scholar]
  3. Flynn M., Darby C., Hyland J., Hammond P., Taylor I. The effect of bile acids on colonic myoelectrical activity. Br J Surg. 1979 Nov;66(11):776–779. doi: 10.1002/bjs.1800661106. [DOI] [PubMed] [Google Scholar]
  4. Kirwan W. O., Smith A. N., Mitchell W. D., Falconer J. D., Eastwood M. A. Bile acids and colonic motility in the rabbit and the human. Gut. 1975 Nov;16(11):894–902. doi: 10.1136/gut.16.11.894. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Mekjian H. S., Phillips S. F., Hofmann A. F. Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man. J Clin Invest. 1971 Aug;50(8):1569–1577. doi: 10.1172/JCI106644. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Milton-Thompson G. J., Cummings J. H., Newman A., Billings J. A., Misiewicz J. J. Colonic and small intestinal response to intravenous prostaglandin F2 alpha and E2 in man. Gut. 1975 Jan;16(1):42–46. doi: 10.1136/gut.16.1.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Phillips S. F. Diarrhea: a current view of the pathophysiology. Gastroenterology. 1972 Sep;63(6):495–518. [PubMed] [Google Scholar]
  8. Samuel P., Saypoi G. M., Meilman E., Mosbach E. H., Chafizadeh M. Absorption of bile acids from the large bowel in man. J Clin Invest. 1968 Sep;47(9):2070–2078. doi: 10.1172/JCI105892. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Snape W. J., Jr, Carlson G. M., Matarazzo S. A., Cohen S. Evidence that abnormal myoelectrical activity produces colonic motor dysfunction in the irritable bowel syndrome. Gastroenterology. 1977 Mar;72(3):383–387. [PubMed] [Google Scholar]
  10. Szurszewski J. H., Bülbring E. The stimulant action of acetylcholine and catecholamines on the uterus. Philos Trans R Soc Lond B Biol Sci. 1973 Mar 15;265(867):149–156. doi: 10.1098/rstb.1973.0017. [DOI] [PubMed] [Google Scholar]
  11. Taylor I., Darby C., Hammond P., Basu P. Is there a myoelectrical abnormality in the irritable colon syndrome? Gut. 1978 May;19(5):391–395. doi: 10.1136/gut.19.5.391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Taylor I., Darby C., Hammond P. Comparison of rectosigmoid myoelectrical activity in the irritable colon syndrome during relapses and remissions. Gut. 1978 Oct;19(10):923–929. doi: 10.1136/gut.19.10.923. [DOI] [PMC free article] [PubMed] [Google Scholar]

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