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. 1980 Sep;21(9):766–771. doi: 10.1136/gut.21.9.766

Pepsin 1 secretion in chronic peptic ulceration.

V Walker, W H Taylor
PMCID: PMC1419519  PMID: 6776016

Abstract

In patients with peptic ulceration, both vagal stimulation by insulin hypoglycaemia and stimulation by pentagastrin cause pepsin 1 to be secreted into gastric juice. There is a secretory threshold for pepsin 1, below which only pepsins 3 and 5 are secreted. Pepsin 1 accounts for an increasing proportion of the total peptic activity/ml of gastric juice as the total activity increases. Higher concentrations of pepsin 1 in the basal gastric secretion occurred significantly more frequently in patients with duodenal ulcer than with gastric ulcer. In these patients there may be an increased 'background' secretory drive.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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