Skip to main content
Gut logoLink to Gut
. 1980 Apr;21(4):299–304. doi: 10.1136/gut.21.4.299

Effect of a combination of gastrin, secretin, cholecystokinin, glucagon, and gastric inhibitory polypeptide on jejunal absorption in man.

P Poitras, R Modigliani, J J Bernier
PMCID: PMC1419620  PMID: 7429291

Abstract

In 11 conscious volunteers, the jejunal absorption was measured during basal state and during the simultaneous intravenous infusion of small doses of gastrin, secretin, cholecystokinin, glucagon and gastric inhibitory polypeptide. The blood levels of gastrin, secretin, glucagon, and GIP were measured by RIA and were close to those achieved after a meal. The basal net absorption of water and electrolytes was reversed to a net secretion during the hormonal infusion. These results suggest that the jejunal secretion observed after a meal in man may be mediated by hormones released by the meal.

Full text

PDF
303

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Accary J. P., Bonfils S. Le dosage radio-immunologique de la gastrine. Biol Gastroenterol (Paris) 1971;1:79–91. [PubMed] [Google Scholar]
  2. Alford F. P., Bloom S. R., Nabarro J. D., Hall R., Besser G. M., Coy D. H., Kastin A. J., Schally A. V. Glucagon control of fasting glucose in man. Lancet. 1974 Oct 26;2(7887):974–977. doi: 10.1016/s0140-6736(74)92071-6. [DOI] [PubMed] [Google Scholar]
  3. Assan R., Tchobroutsky G., Derot M. Glucagon radioimmunoassay: technical problems and recent data. Horm Metab Res. 1971;3(Suppl):82–90. [PubMed] [Google Scholar]
  4. Boden G., Wilson R. M., Essa-Koumar N., Owen O. E. Effects of a protein meal, intraduodenal HCl, and oleic acid on portal and peripheral venous secretin and on pancreatic bicarbonate secretion. Gut. 1978 Apr;19(4):277–283. doi: 10.1136/gut.19.4.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cook G. C., Carruthers R. H. Reaction of human small intestine to an intraluminal tube and its importance in jejunal perfusion studies. Gut. 1974 Jul;15(7):545–548. doi: 10.1136/gut.15.7.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dupre J., Ross S. A., Watson D., Brown J. C. Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab. 1973 Nov;37(5):826–828. doi: 10.1210/jcem-37-5-826. [DOI] [PubMed] [Google Scholar]
  7. Ertan A., Brooks F. P., Ostrow J. D., Arvan D. A., Williams C. N., Cerda J. J. Effect of jejunal amino acid perfusion and exogenous cholecystokinin on the exocrine pancreatic and biliary secretions in man. Gastroenterology. 1971 Nov;61(5):686–692. [PubMed] [Google Scholar]
  8. Fordtran J. S., Locklear T. W. Ionic constituents and osmolality of gastric and small-intestinal fluids after eating. Am J Dig Dis. 1966 Jul;11(7):503–521. doi: 10.1007/BF02233563. [DOI] [PubMed] [Google Scholar]
  9. Freeland G. R., Higgs R. H., Castell D. O., McGuigan J. E. Lower esophageal sphincter and gastric acid response to intravenous infusions of synthetic human gastrin I heptadecapeptide. Gastroenterology. 1976 Oct;71(4):570–574. [PubMed] [Google Scholar]
  10. Gerich J. E., Lorenzi M., Karam J. H., Schneider V., Forsham P. H. Abnormal pancreatic glucagon secretion and postprandial hyperglycemia in diabetes mellitus. JAMA. 1975 Oct 13;234(2):159–155. [PubMed] [Google Scholar]
  11. Helman C. A., Barbezat G. O. The effect of gastric inhibitory polypeptide on human jejunal water and electrolyte transport. Gastroenterology. 1977 Feb;72(2):376–379. [PubMed] [Google Scholar]
  12. Hicks T., Turnberg L. A. Influence of glucagon on the human jejunum. Gastroenterology. 1974 Dec;67(6):1114–1118. [PubMed] [Google Scholar]
  13. IWATA T., YAMASAKI K. ENZYMATIC DETERMINATION AND THIN-LAYER CHROMATOGRAPHY OF BILE ACIDS IN BLOOD. J Biochem. 1964 Nov;56:424–431. doi: 10.1093/oxfordjournals.jbchem.a128013. [DOI] [PubMed] [Google Scholar]
  14. Klaeveman H. L., Conlon T. P., Levy A. G., Gardner J. D. Effects of gastrointestinal hormones on adenylate cyclase activity in human jejunal mucosa. Gastroenterology. 1975 Apr;68(4 Pt 1):667–675. [PubMed] [Google Scholar]
  15. Kolts B. E., McGuigan J. E. Radioimmunoassay measurement of secretin half-life in man. Gastroenterology. 1977 Jan;72(1):55–60. [PubMed] [Google Scholar]
  16. Kuzio M., Dryburgh J. R., Malloy K. M., Brown J. C. Radioimmunoassay for gastric inhibitory polypeptide. Gastroenterology. 1974 Mar;66(3):357–364. [PubMed] [Google Scholar]
  17. LaRusso N. F., Szczepanik P. A., Hofmann A. F. Effect of deoxycholic acid ingestion on bile acid metabolism and biliary lipid secretion in normal subjects. Gastroenterology. 1977 Jan;72(1):132–140. [PubMed] [Google Scholar]
  18. Lefebvre P. J., Luyckx A. S. The breakfast tolerance test: a return to physiology. Diabete Metab. 1976 Mar;2(1):15–19. [PubMed] [Google Scholar]
  19. Malagelada J. R., Go V. L., Summerskill W. H. Altered pancreatic and biliary function after vagotomy and pyloroplasty. Gastroenterology. 1974 Jan;66(1):22–27. [PubMed] [Google Scholar]
  20. Malagelada J. R., Go V. L., Summerskill W. H. Differing sensitivities of gallbladder and pancreas to cholecystokinin-pancreozymin (CCK-PZ) in man. Gastroenterology. 1973 May;64(5):950–954. [PubMed] [Google Scholar]
  21. Meyer J. H., Way L. W., Grossman M. I. Pancreatic response to acidification of various lengths of proximal intestine in the dog. Am J Physiol. 1970 Oct;219(4):971–977. doi: 10.1152/ajplegacy.1970.219.4.971. [DOI] [PubMed] [Google Scholar]
  22. Mitznegg P., Bloom S. R., Christofides N., Besterman H., Domschke W., Domschke S., Wünsch E., Demling L. Release of motilin in man. Scand J Gastroenterol Suppl. 1976;39:53–56. [PubMed] [Google Scholar]
  23. Modigliani R., Mary J. Y., Bernier J. J. Effect of pentagastrin upon movements of water, electrolytes and glucose across the human jejunum and ileum. Digestion. 1973;8(3):208–219. doi: 10.1159/000197316. [DOI] [PubMed] [Google Scholar]
  24. Modigliani R., Mary J. Y., Bernier J. J. Effects of synthetic human gastrin I on movements on water, electrolytes, and glucose across the human small intestine. Gastroenterology. 1976 Dec;71(6):978–985. [PubMed] [Google Scholar]
  25. Modigliani R., Rambaud J. C., Bernier J. J. The method of intraluminal perfusion of the human small intestine. I. Principle and technique. Digestion. 1973;9(2):176–192. doi: 10.1159/000197443. [DOI] [PubMed] [Google Scholar]
  26. Moritz M., Finkelstein G., Meshkinpour H., Fingerut J., Lorber S. H. Effect of secretin and cholecystokinin on the transport of electrolyte and water in human jejunum. Gastroenterology. 1973 Jan;64(1):76–80. [PubMed] [Google Scholar]
  27. Russell R. I., Allan J. G., Gerskowitch V. P., Cochran K. M. The effect of conjugated and unconjugated bile acids on water and electrolyte absorption in the human jejunum. Clin Sci Mol Med. 1973 Sep;45(3):301–311. doi: 10.1042/cs0450301. [DOI] [PubMed] [Google Scholar]
  28. Stratton C. J. The three-dimensional aspect of the mammalian lung surfactant myelin figure. Tissue Cell. 1977;9(2):285–300. doi: 10.1016/0040-8166(77)90022-2. [DOI] [PubMed] [Google Scholar]
  29. Whalen G. E., Harris J. A., Geenen J. E., Soergel K. H. Sodium and water absorption from the human small intestine. The accuracy of the perfusion method. Gastroenterology. 1966 Dec;51(6):975–984. [PubMed] [Google Scholar]
  30. Wingate D. L., Phillips S. F., Hofmann A. F. Effect of glycine-conjugated bile acids with and without lecithin on water and glucose absorption in perfused human jejunum. J Clin Invest. 1973 May;52(5):1230–1236. doi: 10.1172/JCI107290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Wright J. P., Barbezat G. O., Clain J. E. Jejunal secretion in response to a duodenal mixed nutrient perfusion. Gastroenterology. 1979 Jan;76(1):94–98. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES