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. 1982 Oct;23(10):843–846. doi: 10.1136/gut.23.10.843

Water and electrolyte absorption by the colon in tropical sprue.

B S Ramakrishna, V I Mathan
PMCID: PMC1419837  PMID: 7117904

Abstract

A defect in colonic absorption of electrolytes and water was demonstrated in patients with tropical sprue by perfusing the colon with normal saline containing a non-absorbable marker. Colonic water absorption correlated negatively with stool weight and was abnormal in patients with steatorrhoea. The possible mechanisms producing this defect are discussed. This defect may be related to colonocyte damage produced by unabsorbed unsaturated fatty acids in patients with steatorrhoea.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Banwell J. G., Gorbach S. L., Mitra R., Cassells J. S., Mazumder D. N., Thomas J., Yardley J. H. Tropical sprue and malnutrition in West Bengal. II. Fluid and electrolyte transport in the small intestine. Am J Clin Nutr. 1970 Dec;23(12):1559–1568. doi: 10.1093/ajcn/23.12.1559. [DOI] [PubMed] [Google Scholar]
  2. Banwell J. G., Pierce N. F., Mitra R. C., Brigham K. L., Caranasos G. J., Keimowitz R. I., Fedson D. S., Thomas J., Gorbach S. L., Sack R. B. Intestinal fluid and electrolyte transport in human cholera. J Clin Invest. 1970 Jan;49(1):183–195. doi: 10.1172/JCI106217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Binder H. J., Rawlins C. L. Effect of conjugated dihydroxy bile salts on electrolyte transport in rat colon. J Clin Invest. 1973 Jun;52(6):1460–1466. doi: 10.1172/JCI107320. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Corcino J. J., Maldonado M., Klipstein F. A. Intestinal perfusion studies in tropical sprue. I. Transport of water, electrolytes, and d-xylose. Gastroenterology. 1973 Aug;65(2):192–198. [PubMed] [Google Scholar]
  5. Debongnie J. C., Phillips S. F. Capacity of the human colon to absorb fluid. Gastroenterology. 1978 Apr;74(4):698–703. [PubMed] [Google Scholar]
  6. Devroede G. J., Phillips S. F. Studies of the perfusion technique for colonic absorption. Gastroenterology. 1969 Jan;56(1):92–100. [PubMed] [Google Scholar]
  7. Devroede G., Soffié M. Colonic absorption in idiopathic constipation. Gastroenterology. 1973 Apr;64(4):552–561. [PubMed] [Google Scholar]
  8. Fordtran J. S., Rector F. C., Locklear T. W., Ewton M. F. Water and solute movement in the small intestine of patients with sprue. J Clin Invest. 1967 Mar;46(3):287–298. doi: 10.1172/JCI105531. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hellier M. D., Bhat P., Albert J., Baker S. J. Intestinal perfusion studies in tropical sprue. 2. Movement of water and electrolytes. Gut. 1977 Jun;18(6):480–483. doi: 10.1136/gut.18.6.480. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kapadia C. R., Baker S. J. The increased rate of loss, and non-exponential excretion of bile salts in patients with tropical sprue and ileoctomy. Aust N Z J Med. 1973 Jun;3(3):260–263. doi: 10.1111/j.1445-5994.1973.tb03092.x. [DOI] [PubMed] [Google Scholar]
  11. LEVITAN R., FORDTRAN J. S., BURROWS B. A., INGELFINGER F. J. Water and salt absorption in the human colon. J Clin Invest. 1962 Sep;41:1754–1759. doi: 10.1172/JCI104634. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. LEVITAN R., INGELFINGER F. J. EFFECT OF D-ALDOSTERONE ON SALT AND WATER ABSORPTION FROM THE INTACT HUMAN COLON. J Clin Invest. 1965 May;44:801–808. doi: 10.1172/JCI105192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mathan M., Mathan V. I., Baker S. J. An electron-microscopic study of jejunal mucosal morphology in control subjects and in patients with tropical sprue in southern India. Gastroenterology. 1975 Jan;68(1):17–32. [PubMed] [Google Scholar]
  14. Mekjian H. S., Phillips S. F., Hofmann A. F. Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man. J Clin Invest. 1971 Aug;50(8):1569–1577. doi: 10.1172/JCI106644. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rask-Madsen J. Simultaneous measurement of electrical polarization and electrolyte transport by the entire normal and inflamed human colon during in vivo perfusion. Scand J Gastroenterol. 1973;8(4):327–336. [PubMed] [Google Scholar]
  16. Regarding the definition of tropical sprue. Gastroenterology. 1970 May;58(5):717–721. [PubMed] [Google Scholar]

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