Skip to main content
PMC home page
Gut logoLink to Gut
. 1980 Jul;21(7):574–579. doi: 10.1136/gut.21.7.574

Pectin and complications after gastric surgery: normalisation of postprandial glucose and endocrine responses.

D J Jenkins, S R Bloom, R H Albuquerque, A R Leeds, D L Sarson, G L Metz, K G Alberti
PMCID: PMC1419882  PMID: 7000630

Abstract

Pectin has been shown to minimise the fall in blood glucose seen in patients who are troubled by hypoglycaemia attacks after gastric surgery. We therefore performed 50 g glucose tolerance tests with and without 14.5 g pectin on 11 post-gastric surgery patients. After pectin, the high postprandial levels of glucose, insulin, and enteroglucagon were significantly reduced as was the fall in blood glucose between 90 and 120 minutes. These effects of pectin may reflect slower uptake of glucose from the gastrointestinal tract and provide evidence to support the use of unabsorbable carbohydrate gelling agents in treating hypoglycaemia after gastric surgery.

Full text

PDF
579

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aagaard P., Deckert T., Fenger H. J. Serum insulin after intravenous administration of glucose before and after total vagotomy. Scand J Gastroenterol. 1973;8(8):699–701. [PubMed] [Google Scholar]
  2. Besterman H. S., Bloom S. R., Sarson D. L., Blackburn A. M., Johnston D. I., Patel H. R., Stewart J. S., Modigliani R., Guerin S., Mallinson C. N. Gut-hormone profile in coeliac disease. Lancet. 1978 Apr 15;1(8068):785–788. doi: 10.1016/s0140-6736(78)92994-x. [DOI] [PubMed] [Google Scholar]
  3. Besterman H. S., Cook G. C., Sarson D. L., Christofides N. D., Bryant M. G., Gregor M., Bloom S. R. Gut hormones in tropical malabsorption. Br Med J. 1979 Nov 17;2(6200):1252–1255. doi: 10.1136/bmj.2.6200.1252. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bloom S. R. An enteroglucagon tumour. Gut. 1972 Jul;13(7):520–523. doi: 10.1136/gut.13.7.520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hall W. H., Sanders L. L., Read R. C. Effect of vagotomy and pyloroplasty: the oral glucose tolerance test. Gastroenterology. 1973 Feb;64(2):217–222. [PubMed] [Google Scholar]
  6. Jenkins D. J., Gassull M. A., Leeds A. R., Metz G., Dilawari J. B., Slavin B., Blendis L. M. Effect of dietary fiber on complications of gastric surgery: prevention of postprandial hypoglycemia by pectin. Gastroenterology. 1977 Aug;73(2):215–217. [PubMed] [Google Scholar]
  7. Jenkins D. J., Wolever T. M., Leeds A. R., Gassull M. A., Haisman P., Dilawari J., Goff D. V., Metz G. L., Alberti K. G. Dietary fibres, fibre analogues, and glucose tolerance: importance of viscosity. Br Med J. 1978 May 27;1(6124):1392–1394. doi: 10.1136/bmj.1.6124.1392. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Linquette M., Fourlinnie J. C., Lagache G. Etude de la glycémie et de l'insulinémie après vagotomie et pyloroplastie chez l'homme. Ann Endocrinol (Paris) 1969 Jan-Feb;30(1):96–102. [PubMed] [Google Scholar]
  9. Paris M., Lenicque P. M. Effets du tétrahydrocannabinol et du cannabidiol sur la cicatrisation et la régénération de la planaire Dugesia tigrina. Therapie. 1975 Jan-Feb;30(1):97–102. [PubMed] [Google Scholar]
  10. Soeldner J. S., Slone D. Critical variables in the radioimmunoassay of serum insulin using the double antibody technic. Diabetes. 1965 Dec;14(12):771–779. doi: 10.2337/diab.14.12.771. [DOI] [PubMed] [Google Scholar]
  11. Sundby F., Jacobsen H., Moody A. J. Purification and characterization of a protein from porcine gut with glucagon-like immunoreactivity. Horm Metab Res. 1976 Sep;8(5):366–371. doi: 10.1055/s-0028-1093615. [DOI] [PubMed] [Google Scholar]
  12. Thomas F. B., Shook D. F., O'Dorisio T. M., Cataland S., Mekhjian H. S., Caldwell J. H., Mazzaferri E. L. Localization of gastric inhibitory polypeptide release by intestinal glucose perfusion in man. Gastroenterology. 1977 Jan;72(1):49–54. [PubMed] [Google Scholar]
  13. Thomford N. R., Sirinek K. R., Crockett S. E., Mazzaferri E. L., Cataland S. Gastric inhibitory polypeptide. Response to oral glucose after vagotomy and pyloroplasty. Arch Surg. 1974 Aug;109(2):177–182. doi: 10.1001/archsurg.1974.01360020039009. [DOI] [PubMed] [Google Scholar]
  14. Thomson J. P., Bloom S. R. Plasma enteroglucagon and plasma volume change after gastric surgery. Clin Sci Mol Med. 1976 Aug;51(2):177–183. doi: 10.1042/cs0510177. [DOI] [PubMed] [Google Scholar]
  15. Trinder P. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol. 1969 Mar;22(2):158–161. doi: 10.1136/jcp.22.2.158. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES