Skip to main content
PMC home page
Gut logoLink to Gut
. 1980 Jul;21(7):587–590. doi: 10.1136/gut.21.7.587

Faecal bile acid concentration of patients with carcinoma or increased risk of carcinoma in the large bowel.

D G Mudd, S T McKelvey, W Norwood, D T Elmore, A D Roy
PMCID: PMC1419892  PMID: 7429321

Abstract

Faecal 3-hydroxy bile acids were assayed enzymatically in patients with carcinoma, or at increased risk of developing carcinoma of the large bowel. No rise in bile acid concentration was demonstrated in patients with ulcerative colitis, previously resected adenoma, or resected carcinoma. Patients with carcinoma, before treatment, had faecal bile acid concentrations similar to control values, and surgery did not affect the mean level. These findings cast doubt on the importance of the 3-hydroxy bile acid concentration in the faeces in the pathogenesis of large bowel cancer.

Full text

PDF
588

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armstrong B., Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer. 1975 Apr 15;15(4):617–631. doi: 10.1002/ijc.2910150411. [DOI] [PubMed] [Google Scholar]
  2. Burkitt D. P. Epidemiology of cancer of the colon and rectum. Cancer. 1971 Jul;28(1):3–13. doi: 10.1002/1097-0142(197107)28:1<3::aid-cncr2820280104>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  3. Doll R. The geographical distribution of cancer. Br J Cancer. 1969 Mar;23(1):1–8. doi: 10.1038/bjc.1969.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Drasar B. S., Irving D. Environmental factors and cancer of the colon and breast. Br J Cancer. 1973 Feb;27(2):167–172. doi: 10.1038/bjc.1973.20. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. GRUNDY S. M., AHRENS E. H., Jr, MIETTINEN T. A. QUANTITATIVE ISOLATION AND GAS--LIQUID CHROMATOGRAPHIC ANALYSIS OF TOTAL FECAL BILE ACIDS. J Lipid Res. 1965 Jul;6:397–410. [PubMed] [Google Scholar]
  6. Hill M. J., Aries V. C. Faecal steroid composition and its relationship to cancer of the large bowel. J Pathol. 1971 Jun;104(2):129–139. doi: 10.1002/path.1711040207. [DOI] [PubMed] [Google Scholar]
  7. Hill M. J., Drasar B. S., Hawksworth G., Aries V., Crowther J. S., Williams R. E. Bacteria and aetiology of cancer of large bowel. Lancet. 1971 Jan 16;1(7690):95–100. doi: 10.1016/s0140-6736(71)90837-3. [DOI] [PubMed] [Google Scholar]
  8. Hill M. J., Drasar B. S., Williams R. E., Meade T. W., Cox A. G., Simpson J. E., Morson B. C. Faecal bile-acids and clostridia in patients with cancer of the large bowel. Lancet. 1975 Mar 8;1(7906):535–539. doi: 10.1016/s0140-6736(75)91556-1. [DOI] [PubMed] [Google Scholar]
  9. Hill M. J. Steroid nuclear dehydrogenation and colon cancer. Am J Clin Nutr. 1974 Dec;27(12):1475–1480. doi: 10.1093/ajcn/27.12.1475. [DOI] [PubMed] [Google Scholar]
  10. Hill M. J. The effect of some factors on the faecal concentration of acid steroids, neutral steroids and urobilins. J Pathol. 1971 Aug;104(4):239–245. doi: 10.1002/path.1711040405. [DOI] [PubMed] [Google Scholar]
  11. Miettinen T. A. The role of bile salts in diarrhoea of patients with ulcerative colitis. Gut. 1971 Aug;12(8):632–635. doi: 10.1136/gut.12.8.632. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Reddy B. S., Martin C. W., Wynder E. L. Fecal bile acids and cholesterol metabolites of patients with ulcerative colitis, a high-risk group for development of colon cancer. Cancer Res. 1977 Jun;37(6):1697–1701. [PubMed] [Google Scholar]
  13. Reddy B. S., Weisburger J. H., Wynder E. L. Effects of high risk and low risk diets for colon carcinogenesis on fecal microflora and steroids in man. J Nutr. 1975 Jul;105(7):878–884. doi: 10.1093/jn/105.7.878. [DOI] [PubMed] [Google Scholar]
  14. Reddy B. S., Wynder E. L. Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps. Cancer. 1977 Jun;39(6):2533–2539. doi: 10.1002/1097-0142(197706)39:6<2533::aid-cncr2820390634>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  15. Watne A. L., Lai H. Y., Mance T., Core S. Fecal steroids and bacterial flora in patients with polyposis coli. Am J Surg. 1976 Jan;131(1):42–46. doi: 10.1016/0002-9610(76)90418-9. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES