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. 1980 Jul;21(7):561–564. doi: 10.1136/gut.21.7.561

Reduced leucocyte zinc in liver disease.

P W Keeling, R B Jones, P J Hilton, R P Thompson
PMCID: PMC1419894  PMID: 7429319

Abstract

The zinc content of peripheral blood leucocytes has been measured in normal controls and in three groups of patients with liver disease. A significant reduction in leucocyte zinc, but not erythrocyte zinc, was observed in patients with primary biliary cirrhosis, alcoholic cirrhosis, and active chronic hepatitis. It is suggested that the nucleated tissues of some patients with liver disease are therefore zinc deficient, and that leucocyte zinc may prove of value in the assessment of the zinc status of such patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alam A. N., Wheeler P., Wilkinson S. P., Poston L., Golindano C., Williamss R. Changes in the electrolyte content of leucocytes at different clinical stages of cirrhosis. Gut. 1978 Jul;19(7):650–654. doi: 10.1136/gut.19.7.650. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baron D. N., Ahmed S. A. Intracellular concentrations of water and of the principal electrolytes determined by analysis of isolated human leucocytes. Clin Sci. 1969 Aug;37(1):205–219. [PubMed] [Google Scholar]
  3. Boyett J. D., Sullivan J. F. Zinc and collagen content of cirrhotic liver. Am J Dig Dis. 1970 Sep;15(9):797–802. doi: 10.1007/BF02236039. [DOI] [PubMed] [Google Scholar]
  4. Calhoun N. R., Smith J. C., Jr, Becker K. L. The role of zinc in bone metabolism. Clin Orthop Relat Res. 1974;(103):212–234. doi: 10.1097/00003086-197409000-00084. [DOI] [PubMed] [Google Scholar]
  5. FREDRICKS R. E., TANAKA K. R., VALENTINE W. N. Zinc in human blood cells: normal values and abnormalities associated with liver disease. J Clin Invest. 1960 Nov;39:1651–1656. doi: 10.1172/JCI104188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Giroux E. L., Durieux M., Schechter P. J. A study of zinc distribution in human serum. Bioinorg Chem. 1976;5(3):211–218. doi: 10.1016/s0006-3061(00)82019-0. [DOI] [PubMed] [Google Scholar]
  7. Lindeman R. D., Baxter D. J., Yunice A. A., Kraikitpanitch S. Serum concentrations and urinary excretions of zinc in cirrhosis, nephrotic syndrome and renal insufficiency. Am J Med Sci. 1978 Jan-Feb;275(1):17–31. doi: 10.1097/00000441-197801000-00002. [DOI] [PubMed] [Google Scholar]
  8. Prasad A. S., Oberleas D. Binding of zinc to amino acids and serum proteins in vitro. J Lab Clin Med. 1970 Sep;76(3):416–425. [PubMed] [Google Scholar]
  9. Prasad A. S., Oberleas D., Halsted J. A. Determination of zinc in biological fluids by atomic absorption spectrophotometry in normal and cirrhotic subjects. J Lab Clin Med. 1965 Sep;66(3):508–516. [PubMed] [Google Scholar]
  10. Prasad A. S., Rabbani P., Abbasii A., Bowersox E., Fox M. R. Experimental zinc deficiency in humans. Ann Intern Med. 1978 Oct;89(4):483–490. doi: 10.7326/0003-4819-89-4-483. [DOI] [PubMed] [Google Scholar]
  11. SULLIVAN J. F., LANKFORD H. G. ZINC METABOLISM AND CHRONIC ALCOHOLISM. Am J Clin Nutr. 1965 Aug;17:57–63. doi: 10.1093/ajcn/17.2.57. [DOI] [PubMed] [Google Scholar]
  12. Schechter P. J., Giroux E. L., Schlienger J. L., Hoenig V., Sjoerdsma A. Distribution of serum zinc between albumin and alpha2-macroglobulin in patients with decompensated hepatic cirrhosis. Eur J Clin Invest. 1976 Mar 31;6(2):147–150. doi: 10.1111/j.1365-2362.1976.tb00505.x. [DOI] [PubMed] [Google Scholar]
  13. VALLEE B. L., WACKER W. E., BARTHOLOMAY A. F., HOCH F. L. Zinc metabolism in hepatic dysfunction. II. Correlation of metabolic patterns with biochemical findings. N Engl J Med. 1957 Nov 28;257(22):1055–1065. doi: 10.1056/NEJM195711282572201. [DOI] [PubMed] [Google Scholar]

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