Abstract
The effect of oral omeprazole on pentagastrin stimulated gastric acid secretion was studied in 11 healthy subjects. Doses of 20-80 mg produced dose dependent inhibition of acid secretion, with total suppression at the highest dose. Omeprazole was absorbed and eliminated from plasma rapidly and the inhibitory effect was related to the area under the plasma concentration time curve. The duration of action was long and single doses of 20 and 40 mg reduced acid secretion significantly for one and three days, respectively. Omeprazole in a dose of 15 mg given once daily for five days, suppressed acid secretion continuously, the inhibitory effect stabilising after three days at a predose inhibition of about 30% and a postdose inhibition of about 80%.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Domschke W., Lux G., Domschke S. Furan H2-antagonist ranitidine inhibits pentagastrin-stimulated gastric secretion stronger than cimetidine. Gastroenterology. 1980 Dec;79(6):1267–1271. [PubMed] [Google Scholar]
- Fellenius E., Berglindh T., Sachs G., Olbe L., Elander B., Sjöstrand S. E., Wallmark B. Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase. Nature. 1981 Mar 12;290(5802):159–161. doi: 10.1038/290159a0. [DOI] [PubMed] [Google Scholar]
- Olbe L., Berglindh T., Elander B., Helander H., Fellenius E., Sjöstrand S. E., Sundell G., Wallmark B. Properties of a new class of gastric acid inhibitors. Scand J Gastroenterol Suppl. 1979;55:131–135. [PubMed] [Google Scholar]
- Saccomani G., Helander H. F., Crago S., Chang H. H., Dailey D. W., Sachs G. Characterization of gastric mucosal membranes. X. Immunological studies of gastric (H+ + K+)-ATPase. J Cell Biol. 1979 Nov;83(2 Pt 1):271–283. doi: 10.1083/jcb.83.2.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sachs G., Chang H. H., Rabon E., Schackman R., Lewin M., Saccomani G. A nonelectrogenic H+ pump in plasma membranes of hog stomach. J Biol Chem. 1976 Dec 10;251(23):7690–7698. [PubMed] [Google Scholar]