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. 1983 Feb;24(2):143–147. doi: 10.1136/gut.24.2.143

Relationship between HBV-specific DNA polymerase and HBe antigen/antibody system in chronic HBV infection: factors determining selection of patients and outcome of antiviral therapy.

A Craxi, I V Weller, M F Bassendine, M J Fowler, J Monjardino, H C Thomas, S Sherlock
PMCID: PMC1420182  PMID: 6852624

Abstract

The sera of 23% of HBe antigen positive patients with chronic hepatitis are HBV-DNA polymerase negative. These patients are probably undergoing spontaneous seroconversion from a state of high to low viral replication and do not require antiviral therapy. In chronic HBV infection rapid changes in viral replication as a result of antiviral therapy are reflected by changes in HBV-DNA and HBV-DNA polymerase but not by changes in HBe antigen concentrations. Disappearance of HBe antigen from serum may be delayed for 180 days after permanent inhibition of HBV replication with adenine arabinoside or its monophosphate derivative.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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