Skip to main content
PMC home page
Gut logoLink to Gut
. 1983 Aug;24(8):746–750. doi: 10.1136/gut.24.8.746

Neutrophil adherence in chronic liver disease and fulminant hepatic failure.

M Altin, I A Rajkovic, R D Hughes, R Williams
PMCID: PMC1420233  PMID: 6873736

Abstract

Abnormal adherence of neutrophils to nylon fibre in vitro was found in blood from 17 of 51 (33.3%) patients with chronic or acute liver disease of different aetiologies. Patients with chronic liver disease had a much wider range of values than the controls and the sub-group with alcoholic cirrhosis had significantly higher adherence (72.4 +/- SD 6.2%) than that of controls (65.8 +/- SD 5.2%). The patients with chronic active hepatitis (68.2 +/- 12.7%) or primary biliary cirrhosis (69.2 +/- 6.6%) were not different from controls. Significantly reduced neutrophil adherence (56.2 +/- 8.7%) was found in blood from patients with fulminant hepatic failure. These abnormalities in neutrophil adherence may be due to the effects of the split components of serum complement and dependent on the degree and duration of exposure of the neutrophils. Defects in neutrophil adherence may in part contribute to the increased susceptibility to infection in patients with acute and chronic liver disease.

Full text

PDF
750

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Campbell A. C., Dronfield M. W., Toghill P. J., Reeves W. G. Neutrophil function in chronic liver disease. Clin Exp Immunol. 1981 Jul;45(1):81–89. [PMC free article] [PubMed] [Google Scholar]
  2. Craddock P. R., Fehr J., Dalmasso A. P., Brighan K. L., Jacob H. S. Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes. J Clin Invest. 1977 May;59(5):879–888. doi: 10.1172/JCI108710. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DeMeo A. N., Andersen B. R. Defective chemotaxis associated with a serum inhibitor in cirrhotic patients. N Engl J Med. 1972 Apr 6;286(14):735–740. doi: 10.1056/NEJM197204062861401. [DOI] [PubMed] [Google Scholar]
  4. Feliu E., Gougerot M. A., Hakim J., Cramer E., Auclair C., Rueff B., Boivin P. Blood polymorphonuclear dysfunction in patients with alcoholic cirrhosis. Eur J Clin Invest. 1977 Dec;7(6):571–577. doi: 10.1111/j.1365-2362.1977.tb01653.x. [DOI] [PubMed] [Google Scholar]
  5. Gazzard B. G., Portmann B., Murray-Lyon I. M., Williams R. Causes of death in fulminant hepatic failure and relationship to quantitative histological assessment of parenchymal damage. Q J Med. 1975 Oct;44(176):615–626. [PubMed] [Google Scholar]
  6. Jones E. A., Sherlock S., Crowley N. Bacteraemia in association with hepatocellular and hepatobiliary disease. Postgrad Med J. 1967 Mar;43(Suppl):7–11. [PubMed] [Google Scholar]
  7. Mac Gregor R. R. Granulocyte adherence changes induced by hemodialysis, endotoxin, epinephrine, and glucocorticoids. Ann Intern Med. 1977 Jan;86(1):35–39. doi: 10.7326/0003-4819-86-1-35. [DOI] [PubMed] [Google Scholar]
  8. MacGregor R. R., Macarak E. J., Kefalides N. A. Comparative adherence of granulocytes to endothelial monolayers and nylon fiber. J Clin Invest. 1978 Mar;61(3):697–702. doi: 10.1172/JCI108981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. MacGregor R. R., Spagnuolo P. J., Lentnek A. L. Inhibition of granulocyte adherence by ethanol, prednisone, and aspirin, measured with an assay system. N Engl J Med. 1974 Sep 26;291(13):642–646. doi: 10.1056/NEJM197409262911302. [DOI] [PubMed] [Google Scholar]
  10. Maderazo E. C., Ward P. A., Quintiliani R. Defective regulation of chemotaxis in cirrhosis. J Lab Clin Med. 1975 Apr;85(4):621–630. [PubMed] [Google Scholar]
  11. Mummery R. V., Bradley J. M., Jeffries D. J. Microbiological monitoring of patients in hepatic failure with particular reference to extracorporeal porcine liver perfusion. Lancet. 1971 Jul 10;2(7715):60–64. doi: 10.1016/s0140-6736(71)92042-3. [DOI] [PubMed] [Google Scholar]
  12. Penner E., Albini B., Milgrom F. Detection of circulating immune complexes in alcoholic liver disease. Clin Exp Immunol. 1978 Oct;34(1):28–31. [PMC free article] [PubMed] [Google Scholar]
  13. Stecher V. J., Chinea G. L. The neutrophil adherence assay as a method for detecting unique anti-inflammatory agents. Agents Actions. 1978 Apr;8(3):258–262. doi: 10.1007/BF01966612. [DOI] [PubMed] [Google Scholar]
  14. TISDALE W. A. Spontaneous colon bacillus bacteremia in Laennec's cirrhosis. Gastroenterology. 1961 Jan;40:141–148. [PubMed] [Google Scholar]
  15. Thomas H. C., McSween R. N., White R. G. Role of the liver in controlling the immunogenicity of commensal bacteria in the gut. Lancet. 1973 Jun 9;1(7815):1288–1291. doi: 10.1016/s0140-6736(73)91300-7. [DOI] [PubMed] [Google Scholar]
  16. Van Epps D. E., Strickland R. G., Williams R. C., Jr Inhibitors of leukocyte chemotaxis in alcoholic liver disease. Am J Med. 1975 Aug;59(2):200–207. doi: 10.1016/0002-9343(75)90354-x. [DOI] [PubMed] [Google Scholar]
  17. WHIPPLE R. L., Jr, HARRIS J. F. B. coli septicemia in Laennec's cirrhosis of the liver. Ann Intern Med. 1950 Aug;33(2):462–466. doi: 10.7326/0003-4819-33-2-462. [DOI] [PubMed] [Google Scholar]
  18. Ward P. A., Becker E. L. The deactivation of rabbit neutrophils by chemotactic factor and the nature of the activatable esterase. J Exp Med. 1968 Apr 1;127(4):693–709. doi: 10.1084/jem.127.4.693. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Wozniak K. J., Silverman E. M. Granulocytic adherence in chronic alcoholism. Am J Clin Pathol. 1979 Mar;71(3):269–272. doi: 10.1093/ajcp/71.3.269. [DOI] [PubMed] [Google Scholar]
  20. Wyke R. J., Rajkovic I. A., Eddleston A. L., Williams R. Defective opsonisation and complement deficiency in serum from patients with fulminant hepatic failure. Gut. 1980 Aug;21(8):643–649. doi: 10.1136/gut.21.8.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Wyke R. J., Yousif-Kadaru A. G., Rajkovic I. A., Eddleston A. L., Williams R. Serum stimulatory activity and polymorphonuclear leucocyte movement in patients with fulminant hepatic failure. Clin Exp Immunol. 1982 Nov;50(2):442–449. [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES