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. 1994 Apr;81(4):631–636.

The importance of interferon-gamma in an early infection of Chlamydia psittaci in mice.

M C McCafferty 1, S W Maley 1, G Entrican 1, D Buxton 1
PMCID: PMC1422362  PMID: 8039814

Abstract

Athymic mice (nu/nu) and their hairy littermates (nu/+) were infected experimentally with Chlamydia psittaci and the role of endogenous interferon-gamma (IFN-gamma) on the resolution of the infection was studied. The pathological changes produced in the spleen, liver and lung were exacerbated by administration of a monoclonal antibody (mAb) to IFN-gamma and an increased number of viable chlamydiae were recovered from the tissues of both nu/+ and nu/nu mice treated in this way.

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Selected References

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