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. 1973 Feb;24(2):191–202.

The primary and secondary antibody response to Escherichia coli O6 lipopolysaccharide analysed at the humoral and cellular level

Amount and avidity of the antibodies in relation to protective capacity

S Ahlstedt, J Holmgren, L Å Hanson
PMCID: PMC1423004  PMID: 4571425

Abstract

The primary and secondary antibody response in inbred CBA mice against Escherichia coli O6 lipopolysaccharide was investigated. The avidity was found to be inversely related to the immunization dose. An optimally immunogenic dose resulted in a maximal IgM production on day 4 and a significant IgG production around day 30. Concomitant to the IgG formation there was an increase in avidity both at the serum level and at the level of the IgM-secreting cells.

A time-dependent immunological memory was noted; a booster dose 28 days after priming gave rise to increased IgM and IgG antibody production as compared to the primary response while a booster dose 10 days after priming did not. The antibody avidity in the secondary response was similar to that in the primary response.

The protective capacity of the immune response seemed to be primarily related to the antibody level. However, high avidity of the IgG antibody population seemed to compensate partially for low amount.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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