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. 1973 Nov;25(5):783–792.

The level and distribution of antibody in syngeneic and allogeneic mated pregnant mice pre-immunized with H-2 alloantigens

G M Taylor
PMCID: PMC1423036  PMID: 4586737

Abstract

The antibody profile of syngeneic and allogeneic (donor) mated female mice, previously actively immunized with allogeneic spleen cells was measured during pregnancy. Marked differences were found, since syngeneic mated females showed a transient fall in antibody titre, whilst allogeneic mated females showed a strong upsurge in antibody titre, from the last week of pregnancy to well after parturition. The level of alloantibody in the serum of the syngeneic and semi-allogeneic progeny of these matings was markedly different.

Immunofluorescent studies on lymphoid cells from the semi-allogeneic progeny of immune females revealed a significant number carrying an immunoglobulin which was concluded to be alloantibody on the basis of control experiments. The differences in maternal alloantibody production profiles were attributed either to an alteration in immunoregulation of antibody synthesis in allogeneic mated females caused by absorption of antibody by the semi-allogeneic progeny in utero, or to secondary response to foetally-derived allogeneic antigens, or the synergistic action of both.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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